Strain Summary[not specified]-Braftm1Mmcm/+ Ptentm2Mak Tg(Tyr-cre/ERT2)13Bos

Strain Name

[not specified]-Braftm1Mmcm/+ Ptentm2Mak Tg(Tyr-cre/ERT2)13Bos

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

BrafCA/+; CreER+/0; Ptenlox/lox

Description

Heterozygous Braf, homozygous Pten mutant mice also carrying the Tg(Tyr-cre/ERT2)13Bos transgene on an unspecified background with possible contribution from 129P2/OlaHsd, 129/SvPas, and/or FVB.

Strain Genetics

Braftm1Mmcm / Braf+
Tg(Tyr-cre/ERT2)13Bos
Tg(Tyr-cre/ERT2)13Bos
Braftm1Mmcm / Braf+
Tg(Tyr-cre/ERT2)13Bos

Models

1 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin - Melanocyte melanoma Skin - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

observed

References: Lee EK, Mol Cell Biol 2013 Nov;33(22):4422-33