Strain Summary[not specified]-Braftm1Mmcm/+ Ccnd1tm1Wbg Fbxo4tm1.1Jadi/+ Tg(Tyr-cre/ERT2)13Bos

Strain Name

[not specified]-Braftm1Mmcm/+ Ccnd1tm1Wbg Fbxo4tm1.1Jadi/+ Tg(Tyr-cre/ERT2)13Bos

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

BrafCA/+; CreER+/0; Fbxo4+/-; Ccnd1-/-

Description

Heterozygous Braf, Fbxo4, homozygous Ccnd1 mutant mice also carrying the Tg(Tyr-cre/ERT2)13Bos transgene on an unspecified background with possible contribution from 129P2/OlaHsd, 129/SvPas, and/or FVB.

Strain Genetics

Fbxo4tm1.1Jadi / Fbxo4+
Braftm1Mmcm / Braf+
Tg(Tyr-cre/ERT2)13Bos
Tg(Tyr-cre/ERT2)13Bos
Braftm1Mmcm / Braf+
Tg(Tyr-cre/ERT2)13Bos

Models

1 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin - Melanocyte melanoma Skin - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

0

References: Lee EK, Mol Cell Biol 2013 Nov;33(22):4422-33