Strain Summary[not specified]-Braftm1Mmcm/+ Fbxo4tm1.1Jadi/+ Tg(Tyr-cre/ERT2)13Bos

Strain Name

[not specified]-Braftm1Mmcm/+ Fbxo4tm1.1Jadi/+ Tg(Tyr-cre/ERT2)13Bos

Strain Type(s)

targeted mutation (knock-in)  •  targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

BrafCA/+; CreER+/0; Fbxo4+/-

Description

Heterozygous Braf, Fbxo4 mutant mice also carrying the Tg(Tyr-cre/ERT2)13Bos transgene on an unspecified background with possible contribution from 129P2/OlaHsd and FVB.

Strain Genetics

Fbxo4tm1.1Jadi / Fbxo4+
Braftm1Mmcm / Braf+
Tg(Tyr-cre/ERT2)13Bos
Tg(Tyr-cre/ERT2)13Bos
Braftm1Mmcm / Braf+
Tg(Tyr-cre/ERT2)13Bos

Models

4 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin - Melanocyte hyperplasia Muzzle 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

observed

References: Lee EK, Mol Cell Biol 2013 Nov;33(22):4422-33

Skin - Melanocyte melanoma Skin - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

73.33

References: Lee EK, Mol Cell Biol 2013 Nov;33(22):4422-33

Skin - Melanocyte nevus - melanocytic Skin - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

observed

References: Lee EK, Mol Cell Biol 2013 Nov;33(22):4422-33

Skin - Melanocyte tumor Skin - Melanocyte 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)

observed

References: Lee EK, Mol Cell Biol 2013 Nov;33(22):4422-33