Mouse Tumor Biology Database (MTB)
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Last Database Update
MTB 3.0
HelpHelp and Documentation Strain Tumor Overview
Collapsed View
[not specified]-Nf2tm2Gth Trp53tm1Brd Tg(Mpz-cre)2Brn
Strain Synonyms [not specified]-Nf2tm2Gth Tg(Mpz-cre)2Brn Trp53tm1Brd  •  [not specified]-Nf2tm2Gth Tg(P0-Cre)2Gth Trp53tm1Brd  •  P0CreB;Nf2flox2/flox2;p53-/-
Strain Note: Mice were homozygous for the Nf2 and Trp53 mutant alleles and carried the transgene. The genetic background of these mice was not specified but carried possible contributions from 129P2/OlaHsd, FVB/N, and 129S7/SvEvBrd.
Strain Tumor Overview Expanded View
Tumors 12 unique tumor types displayed.

A tumor group is a set of tumors that share the same tumor name, organ(s) affected, and treatment type.

Tumor Name Organ(s) Affected Treatment Type Number of
Tumor Group Records
Frequency Range
Bone hyperplasia Bone None (spontaneous) 1 25
Bone metaplasia - osseous Bone None (spontaneous) 1 37.5
Bone osteoma Bone None (spontaneous) 1 12.5
Bone osteosarcoma Bone None (spontaneous) 1 12.5
Kidney - Renal tubule hyperplasia Kidney - Renal tubule None (spontaneous) 1 62.5
Mesodermal cell/mesoblast sarcoma - endothelial Blood vessel None (spontaneous) 1 62.5
Mesodermal cell/mesoblast sarcoma - undifferentiated Mesodermal cell/mesoblast None (spontaneous) 1 25
Mesodermal cell/mesoblast sarcoma - undifferentiated PNS - Ganglion None (spontaneous) 1 observed
Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal None (spontaneous) 1 12.5
PNS - Nerve sheath tumor - malignant PNS - Nerve sheath None (spontaneous) 1 50
PNS - Nerve sheath tumor - malignant PNS - Ganglion None (spontaneous) 1 observed
PNS - Schwann cell hyperplasia PNS - Schwann cell None (spontaneous) 1 37.5