Strain SummaryC57BL/6J-Apctm1.1Alew/+ Gt(ROSA)26Sortm1Hjf Lgr5tm1(cre/ERT2)Cle Rac1tm1Tyb

Strain Name

C57BL/6J-Apctm1.1Alew/+ Gt(ROSA)26Sortm1Hjf Lgr5tm1(cre/ERT2)Cle Rac1tm1Tyb

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  targeted mutation (other)

Strain Synonym(s)

Lgr5GFP-CREER Apc1322T/+ Rac1fl/fl

Description

Het Apc, homozygous Rac1 mutant mice carrying Lgr5tm1(cre/ERT2)Cle & Gt(ROSA)26Sortm1Hjf on a predominantly C57BL/6J background with some possible C57BL/6, 129, 129S4/SvJae, and/or 129P2/OlaHsd.

Strain Genetics

Lgr5tm1(cre/ERT2)Cle / Lgr5?
Lgr5tm1(cre/ERT2)Cle / Lgr5?
Gt(ROSA)26Sortm1Hjf
Apctm1.1Alew / Apc+
Lgr5tm1(cre/ERT2)Cle / Lgr5?

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine adenoma Intestine

observed

References: Myant KB, Cell Stem Cell 2013 Jun 6;12(6):761-73

Intestine adenoma Intestine tamoxifen (For inducing expression from mutant alleles)

observed

References: Myant KB, Cell Stem Cell 2013 Jun 6;12(6):761-73