Strain SummaryC57BL/6J-Apctm1.1Alew/+ Gt(ROSA)26Sortm1Hjf Lgr5tm1(cre/ERT2)Cle

Strain Name

C57BL/6J-Apctm1.1Alew/+ Gt(ROSA)26Sortm1Hjf Lgr5tm1(cre/ERT2)Cle

Strain Type(s)

targeted mutation (knock-in)  •  targeted mutation (other)  •  transgenic

Strain Synonym(s)

Lgr5GFP-CREER Apc1322T

Description

Heterozygous Apc mutant mice carrying the Lgr5tm1(cre/ERT2)Cle and Gt(ROSA)26Sortm1Hjf alleles on a predominantly C57BL/6J background with possible contributions from C57BL/6, 129, 129S4/SvJae, and 129P2/OlaHsd.

Strain Genetics

Lgr5tm1(cre/ERT2)Cle / Lgr5?
Lgr5tm1(cre/ERT2)Cle / Lgr5?
Gt(ROSA)26Sortm1Hjf
Apctm1.1Alew / Apc+
Lgr5tm1(cre/ERT2)Cle / Lgr5?

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine adenoma Intestine tamoxifen (For inducing expression from mutant alleles)

observed

References: Myant KB, Cell Stem Cell 2013 Jun 6;12(6):761-73

Intestine adenoma Intestine

observed

References: Myant KB, Cell Stem Cell 2013 Jun 6;12(6):761-73