Strain Summary[not specified]-Krastm1Bbd/+ Ptentm1Mak Tg(Cyp1a1-cre/ERT)1Dwi

Strain Name

[not specified]-Krastm1Bbd/+ Ptentm1Mak Tg(Cyp1a1-cre/ERT)1Dwi

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knock-in)  •  transgenic

Strain Synonym(s)

AhCreERT+;Ptenf/f;KrasLSL-V12/+  •  Ptenf/f;KrasLSL-V12/+

Description

Homozygous Pten, heterozygous Kras mutant mice on an unspecified background also carrying the Tg(Cyp1a1-cre/ERT)1Dwi transgene. Background may have contributions from 129X1/SvJ, 129S1/Sv, 129P2/OlaHsd, CBA, and/or C57BL/6.

Strain Genetics

Tg(Cyp1a1-cre/ERT)1Dwi
Tg(Cyp1a1-cre/ERT)1Dwi
Krastm1Bbd / Kras+

Models

17 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Forestomach hyperplasia - epithelial Forestomach tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder - Epithelium dysplasia - high grade Gallbladder - Epithelium tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder - Epithelium dysplasia - low grade Gallbladder - Epithelium tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder - Epithelium neoplasm Gallbladder - Epithelium tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

100

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder adenocarcinoma Gallbladder tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder carcinoma - invasive Gallbladder tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

30

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder hyperplasia Gallbladder tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder lesion Gallbladder tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Gallbladder neoplasm - papillary Gallbladder tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

high

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Bile duct dysplasia Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Bile duct dysplasia - high grade Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

40

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Bile duct dysplasia - low grade Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

100

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Bile duct lesion Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

100

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Bile duct neoplasia Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

100

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Bile duct neoplasm - papillary Liver - Bile duct tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed - 100

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Liver - Hepatocyte lesion - proliferative Liver - Hepatocyte tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

0

References: Marsh V, J Pathol 2013 Jun;230(2):165-73

Skin squamous cell papilloma Skin tamoxifen (For inducing expression from mutant alleles)   ⋅   beta-naphthoflavone (betaNF)

observed

References: Marsh V, J Pathol 2013 Jun;230(2):165-73