Strain SummaryC57BL/6-Akt2tm1Rsg Ptentm1Ppp/+

Strain Name

C57BL/6-Akt2tm1Rsg Ptentm1Ppp/+

Strain Type(s)

targeted mutation (knockout)

Strain Synonym(s)

Pten+/- Akt2-/-  •  Pten+/- Akt2-/-

Description

Heterozygous Pten, homozygous Akt2 mice on a C57BL/6 background with contributions from at least DBA/1LacJ.

Strain Genetics

Ptentm1Ppp / Pten+

Models

11 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Medulla neoplasia Adrenal gland - Medulla

observed

observed

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Intestine polyp Intestine

80

90

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Prostate gland prostatic intraepithelial neoplasia - high grade (HGPIN) Prostate gland - Anterior lobe

100

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Prostate gland prostatic intraepithelial neoplasia - high grade (HGPIN) Prostate gland - Dorsolateral lobe

100

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Prostate gland prostatic intraepithelial neoplasia - high grade (HGPIN) Prostate gland - Ventral lobe

100

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Thyroid gland neoplasia Thyroid gland

32

40

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Thyroid gland tumor Thyroid gland

42

42

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Uterus - Endometrium carcinoma in situ Uterus - Endometrium

50

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Uterus - Endometrium hyperplasia Uterus - Endometrium

2.78

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Uterus - Endometrium hyperplasia - atypical - mild Uterus - Endometrium

5.56 - 25

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26

Uterus - Endometrium hyperplasia - atypical - moderate Uterus - Endometrium

13.89

References: Xu PZ, Oncogene 2012 Jan 26;31(4):518-26