Strain SummaryC57BL/6-Mknk1tm1Fuku/+ Mknk2tm1Fuku/+ Ptentm2Mak Tg(Lck-cre)548Jxm

Strain Name

C57BL/6-Mknk1tm1Fuku/+ Mknk2tm1Fuku/+ Ptentm2Mak Tg(Lck-cre)548Jxm

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

tPten-/- Mnk1+/-Mnk2+/-

Description

Mice were backcrossed at least 6 times to C57BL/6N or C57BL/6J and contained contributions from 129X1/SvJ, 129S1/Sv, 129P2/OlaHsd, and CBA. Heterozygous for knockouts of Mknk1 and Mknk2. Homozygous for Pten conditional mutation.

Strain Genetics

Tg(Lck-cre)548Jxm
Mknk2tm1Fuku / Mknk2+
Mknk1tm1Fuku / Mknk1+

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Leukocyte - Lymphocyte - T-lymphocyte lymphoma Spleen

observed

References: Ueda T, Proc Natl Acad Sci U S A 2010 Aug 10;107(32):13984-90

2 pathology image(s)

Leukocyte - Lymphocyte - T-lymphocyte lymphoma Thymus

observed

References: Ueda T, Proc Natl Acad Sci U S A 2010 Aug 10;107(32):13984-90

2 pathology image(s)