Strain SummaryC57BL/6-Mknk1tm1Fuku/Mknk1? Mknk2tm1Fuku/Mknk1? Ptentm2Mak Tg(Lck-cre)548Jxm

Strain Name

C57BL/6-Mknk1tm1Fuku/Mknk1? Mknk2tm1Fuku/Mknk1? Ptentm2Mak Tg(Lck-cre)548Jxm

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

tPten-/-; non-Mnk-DKO

Description

Mice were backcrossed at least 6 times to C57BL/6N or C57BL/6J & had contributions from 129X1/SvJ, 129S1/Sv, 129P2/OlaHsd, & CBA. Mixed background controls for double KO of Mknk1 & Mknk2. Mice carried WT allele for at least one Mknk.

Strain Genetics

Tg(Lck-cre)548Jxm
Mknk1tm1Fuku / Mknk1?
Mknk2tm1Fuku / Mknk2?

Models

1 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

11 - 73

References: Ueda T, Proc Natl Acad Sci U S A 2010 Aug 10;107(32):13984-90