Strain SummaryC57BL/6-Apctm1Rak/+ Gt(ROSA)26Sortm1(Notch1)Dam Tg(Vil1-cre/ERT2)23Syr

Strain Name

C57BL/6-Apctm1Rak/+ Gt(ROSA)26Sortm1(Notch1)Dam Tg(Vil1-cre/ERT2)23Syr

Strain Type(s)

targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

C57BL/6-Apctm1Rak/+ Gt(ROSA)26Sortm1(Notch1)Dam Tg(Vil-cre/ERT2)23Syr  •  C57BL/6-Apctm1Rak/+ Gt(ROSA)26Sortm1(Notch1)Dam Tg(Vil-cre/ESR1)23Syr  •  N/Apc  •  Notch/Apc  •  VilCreERT2/Nic;Apc+/1638N

Description

Compound mutant mice. These mice are the product of an intercross between strains on a predominantly C57BL/6 background.

Strain Genetics

Tg(Vil1-cre/ERT2)23Syr
Apctm1Rak / Apc+
Gt(ROSA)26Sortm1(Notch1)Dam
Tg(Vil1-cre/ERT2)23Syr
Gt(ROSA)26Sortm1(Notch1)Dam

Models

2 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine - Large Intestine - Colon dysplasia Intestine - Large Intestine - Colon

very low - high

References: Fre S, Proc Natl Acad Sci U S A 2009 Apr 14;106(15):6309-14

Intestine adenoma Intestine

100

References: Fre S, Proc Natl Acad Sci U S A 2009 Apr 14;106(15):6309-14