Strain Summary129S-Krastm2Tyj/+ Trp53tm1Glo/+

Strain Name

129S-Krastm2Tyj/+ Trp53tm1Glo/+

Strain Type(s)

targeted mutation (knock-in)

Strain Synonym(s)

double mutant  •  p53R172HΔg/+ K-rasLA1/+  •  K-rasLA1/+ p53R172HÄg/+  •  p53R172HΔg/+ K-rasLA1/+  •  p53R172HΔg/+;K-rasLA1/+

Description

Double heterozygotes. The genetic background of these mice was stated to be greater than 90% 129/Sv. The other strains involved in this background were not specified.

Strain Genetics

Krastm2Tyj / Kras+
Trp53tm1Glo / Trp53+

Models

17 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Bone osteosarcoma Bone

0

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

5.4

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Intestine - Large Intestine - Rectum adenocarcinoma - mucinous Intestine - Large Intestine - Rectum

0

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Leukocyte lymphoma Leukocyte

11

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Sites of Metastasis: Lung

Lung adenocarcinoma Lung

93

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Sites of Metastasis: (Unspecified organ) , Adrenal gland , Body wall , Eye , Heart , Kidney , Liver , Lymph node - Mediastinal , Lymph node - Mesenteric , Mammary gland , Muscle - Striated - Skeletal - Diaphragm , Pancreas , Pleura - Parietal

Lung adenoma Lung

7.1

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Lung hyperplasia Lung

observed

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Lung hyperplasia - papillary Lung

observed

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Lung tumor Lung

100

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Melanocyte melanoma Melanocyte

0

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Mesodermal cell/mesoblast sarcoma - unclassified Mesodermal cell/mesoblast

3.6

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Mesothelium mesothelioma Pleura - Parietal

23

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Sites of Metastasis: Adipose tissue , Connective tissue , Liver , Lymph node - Mediastinal , Ovary , Pancreas

Mesothelium mesothelioma Peritoneum

11

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

Pancreas carcinoma Pancreas

3.6

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

(Unspecified organ) angiosarcoma (Unspecified organ)

7.1

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

(Unspecified organ) papilloma (Unspecified organ)

16

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904

(Unspecified organ) squamous cell carcinoma (Unspecified organ)

1.8

References: Zheng S, Oncogene 2007 Oct 18;26(48):6896-904