Strain SummaryC57BL/6-Trp53tm3.1Glo/+

Strain Name

C57BL/6-Trp53tm3.1Glo/+

Strain Type(s)

targeted mutation (knock-in)

Strain Synonym(s)

B6.129S7-Trp53tm3.1Glo/+  •  p53+/515A  •  p53 +/515A

Description

Heterozygous mice. These mice are the product of an intercross between strains on a predominantly C57BL/6 background. The genetic backgound also contained some 129S7/SvEvBrd-Hprt+ and possibly some 129S2/SvPas.

Strain Genetics

Trp53tm3.1Glo / Trp53+

Models

14 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Bone osteosarcoma Bone

34

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Sites of Metastasis: (Unspecified organ) , Liver

Leukocyte - Lymphocyte - B-lymphocyte lymphoma - diffuse large cell (DLCL) Leukocyte - Lymphocyte - B-lymphocyte

3.1

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Leukocyte lymphoma Leukocyte

moderate

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Leukocyte lymphoma - unclassified Leukocyte

35

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Lung adenocarcinoma Lung

observed

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Sites of Metastasis: CNS - Brain

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

high

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Mesodermal cell/mesoblast sarcoma - unclassified Mesodermal cell/mesoblast

18

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal

0

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

(Unspecified organ) adenocarcinoma (Unspecified organ)

4.6

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Sites of Metastasis: (Unspecified organ)

(Unspecified organ) angiosarcoma (Unspecified organ)

12

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

(Unspecified organ) carcinoma (Unspecified organ)

low

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

(Unspecified organ) carcinoma - poorly differentiated (Unspecified organ)

3.1

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

(Unspecified organ) squamous cell carcinoma (Unspecified organ)

11

References: Lang GA, Cell 2004 Dec 17;119(6):861-72

Sites of Metastasis: (Unspecified organ)

(Unspecified organ) tumor (Unspecified organ)

high

References: Lang GA, Cell 2004 Dec 17;119(6):861-72