Strain SummarySTOCK Apctm1Rak/+ Rb1tm2Brn Tg(Vil1-cre)20Syr

Strain Name

STOCK Apctm1Rak/+ Rb1tm2Brn Tg(Vil1-cre)20Syr

Strain Type(s)

targeted mutation (conditional)  •  targeted mutation (knockout)  •  transgenic

Strain Synonym(s)

Apc1638N Rbtm2Brn Tg( Vil-Cre)  •  Rb-/-, Apc+/-  •  STOCK Apctm1Rak/+ Rb1tm2Brn Tg(Vil-cre)20Syr

Description

These mice were heterozygous for the Apc allele and homozygous for the Rb1 allele and carried the transgene. This STOCK genetic background was a mixture of 129 (substrain unspecified), 129P2/OlaHsd, FVB, C57BL/6, and DBA/2.

Strain Genetics

Apctm1Rak / Apc+
Tg(Vil1-cre)20Syr

Models

25 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Gastrointestinal tract adenocarcinoma Gastrointestinal tract

33.33

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Gastrointestinal tract adenoma - villous Gastrointestinal tract

33.33

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Gastrointestinal tract tumor Gastrointestinal tract

100

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Large Intestine - Cecum adenoma - villous Intestine - Large Intestine - Cecum

observed

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

1 pathology image(s)

Intestine - Large Intestine - Cecum polyp Intestine - Large Intestine - Cecum

observed

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Intestine - Large Intestine - Cecum tumor Intestine - Large Intestine - Cecum

86.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

1 pathology image(s)

Intestine - Large Intestine - Colon - Distal tumor Intestine - Large Intestine - Colon - Distal

6.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Large Intestine - Colon - Proximal tumor Intestine - Large Intestine - Colon - Proximal

26.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Large Intestine adenocarcinoma Intestine - Large Intestine

0

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Large Intestine adenoma - villous Intestine - Large Intestine

6.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Large Intestine tumor Intestine - Large Intestine

86.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Small Intestine - Duodenum polyp Intestine - Small Intestine - Duodenum

100

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine

33.33

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Small Intestine adenoma - villous Intestine - Small Intestine

26.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Intestine - Small Intestine polyp Intestine - Small Intestine

observed

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

1 pathology image(s)

Intestine - Small Intestine tumor Intestine - Small Intestine

100

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Liver - Bile duct tumor Liver - Bile duct

0

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Liver tumor Liver

0

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Lung tumor Lung

0

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Pituitary gland tumor Pituitary gland

observed

0

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83   ⋅   Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Skin - Hair follicle tumor Skin - Hair follicle

observed

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Stomach polyp Stomach

observed

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83

Stomach tumor Stomach

26.67

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Thyroid gland - Medulla - C cell tumor Thyroid gland - Medulla - C cell

observed

References: Kucherlapati MH, Proc Natl Acad Sci U S A 2008 Oct 7;105(40):15493-8

Thyroid gland tumor Thyroid gland

0

References: Kucherlapati MH, Cancer Res 2006 Apr 1;66(7):3576-83