Mouse Tumor Biology Database (MTB)
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Last Database Update
MTB 3.0
HelpHelp and Documentation Strain Tumor Overview
Collapsed View
B6;129-Cdkn1btm1Ako Trp53tm1Brd
Strain Synonyms p27-/--p53-/-  •  p27/p53 DN  •  p27/p53 double null
Strain Note: Double homozygous mice. The genetic background was a mixture of C57BL/6 and 129/Sv (substrain(s) not specified but included at least 129S1/Sv-p+ Tyr+ Kitl+ and 129S7/SvEvBrd-Hprt1+).
Strain Tumor Overview Expanded View
Tumors 19 unique tumor types displayed.

A tumor group is a set of tumors that share the same tumor name, organ(s) affected, and treatment type.

Tumor Name Organ(s) Affected Treatment Type Number of
Tumor Group Records
Frequency Range
Adrenal gland - Medulla hyperplasia Adrenal gland - Medulla None (spontaneous) 1 12.5
Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla None (spontaneous) 1 19
Blood vessel hemangiosarcoma Spleen None (spontaneous) 1 5.3
Blood vessel hemangiosarcoma Liver None (spontaneous) 1 5.3
Intestine - Large Intestine - Colon adenocarcinoma - papillary Intestine - Large Intestine - Colon None (spontaneous) 1 8.0
Intestine - Large Intestine - Colon adenoma - papillary Intestine - Large Intestine - Colon None (spontaneous) 1 28
Intestine - Large Intestine - Colon hyperplasia - papillary Intestine - Large Intestine - Colon None (spontaneous) 1 8.0
Leukocyte lymphoma Leukocyte None (spontaneous) 17 79
Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast None (spontaneous) 1 58
Mesodermal cell/mesoblast sarcoma - undifferentiated Mesodermal cell/mesoblast None (spontaneous) 1 26
Muscle - Smooth leiomyosarcoma Intestine - Large Intestine - Colon None (spontaneous) 1 21
Pituitary gland adenocarcinoma Pituitary gland None (spontaneous) 2 5.9
Pituitary gland adenoma Pituitary gland None (spontaneous) 1 12
Pituitary gland hyperplasia Pituitary gland None (spontaneous) 1 0
Stomach adenoma - villous Stomach None (spontaneous) 1 5.9
Stomach squamous cell papilloma Stomach None (spontaneous) 1 5.9
Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell) None (spontaneous) 1 12.5
Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell) None (spontaneous) 1 25
(Unspecified organ) tumor (Unspecified organ) None (spontaneous) 1 very high