Mouse Tumor Biology Database (MTB)
MTB Home   Help
Search for Help
 
in these sections
Search Forms
Tumor
Strain
Genetics
Pathology Images
Reference
Advanced
Search MTB Using Human Genes
Gene Expression Data Sets

Additional Resources
new PDX Like Me
PDX Finder
PDX Model Search
Faceted Tumor Search
Dynamic Tumor Frequency Grid
Other Cancer Websites
Immunohistochemistry
Lymphoma Pathology

Mouse Genome Informatics
The Jackson Laboratory
Citing These Resources
Warranty Disclaimer
& Copyright Notice

Send Questions and
Comments to User Support.

Last Database Update
2019-12-08
MTB 3.0
 
HelpHelp and Documentation Strain Tumor Overview
Collapsed View
 
Strain
B6;129-Cdkn2ctm1Yxi Trp53tm1Brd
Strain Synonyms p18-/--p53-/-  •  p18/p53 DN  •  p18/p53 double null
Strain Note: These mice were homozygous for both targeted mutant alleles. The genetic background of these mice was a mixture of C57BL/6 and 129/Sv (substrain(s) not specified but included at least 129S7/SvEvBrd-Hprt1+).
Strain Tumor Overview Expanded View
Tumors 21 unique tumor types displayed.

A tumor group is a set of tumors that share the same tumor name, organ(s) affected, and treatment type.

Tumor Name Organ(s) Affected Treatment Type Number of
Tumor Group Records
Frequency Range
Adrenal gland - Medulla hyperplasia Adrenal gland - Medulla None (spontaneous) 1 15
Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla None (spontaneous) 1 7.7
Blood vessel hemangiosarcoma Blood vessel None (spontaneous) 1 6.25
Blood vessel hemangiosarcoma Ovary None (spontaneous) 1 observed
Bone osteosarcoma Bone None (spontaneous) 2 3.1
Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast None (spontaneous) 1 3.1
Leukocyte lymphoma Leukocyte None (spontaneous) 12 59
Liver hepatocellular carcinoma Liver None (spontaneous) 2 3.1
Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast None (spontaneous) 1 28
Mesodermal cell/mesoblast sarcoma - undifferentiated Mesodermal cell/mesoblast None (spontaneous) 1 12.5
Muscle - Smooth leiomyosarcoma Uterus None (spontaneous) 1 3.1
Pituitary gland adenocarcinoma Pituitary gland None (spontaneous) 1 11
Pituitary gland adenoma Pituitary gland None (spontaneous) 1 0
Pituitary gland hyperplasia Pituitary gland None (spontaneous) 1 0
Stomach squamous cell papilloma Stomach None (spontaneous) 1 6.5
Testis - Leydig cell (Interstitial cell) adenoma Testis - Leydig cell (Interstitial cell) None (spontaneous) 1 6.7
Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell) None (spontaneous) 1 33
Testis choriocarcinoma Testis None (spontaneous) 1 6.7
Thyroid gland - Medulla - C cell adenoma Thyroid gland - Medulla - C cell None (spontaneous) 1 5.0
Thyroid gland - Medulla - C cell hyperplasia Thyroid gland - Medulla - C cell None (spontaneous) 1 0
(Unspecified organ) tumor (Unspecified organ) None (spontaneous) 1 very high