Strain SummaryB6;129S7-Trp53tm1Ldo/+

Strain Name

B6;129S7-Trp53tm1Ldo/+

Strain Type(s)

targeted mutation (knock-in)

Strain Synonym(s)

C57BL/6-129/Sv p53m/+  •  p53m/+

Description

Mice heterozygous for a Trp53 mutation involving an Arg245Trp substitution and a deleted 20 kb of sequence that included exons 1-6 and a large undefined upstream region. Background was mix of C57BL/6 and 129S7/SvEvBrd-Hprt+.

Strain Genetics

Trp53tm1Ldo / Trp53+

Models

6 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Bone osteosarcoma Bone

0

References: Tyner SD, Nature 2002 Jan 3;415(6867):45-53

Leukocyte lymphoma Leukocyte

0

References: Tyner SD, Nature 2002 Jan 3;415(6867):45-53

Lung adenocarcinoma - well-differentiated Lung

2.9

References: Tyner SD, Nature 2002 Jan 3;415(6867):45-53

Lung adenoma Lung

2.9

References: Tyner SD, Nature 2002 Jan 3;415(6867):45-53

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

0

References: Tyner SD, Nature 2002 Jan 3;415(6867):45-53

(Unspecified organ) tumor (Unspecified organ)

5.7

References: Tyner SD, Nature 2002 Jan 3;415(6867):45-53