Strain SummaryB6;129P2-Ptentm2Mak Tg(KRT5-cre)1Tak

Strain Name

B6;129P2-Ptentm2Mak Tg(KRT5-cre)1Tak

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

k5CrePtenflox/flox  •  k5Ptenflox/flox  •  Keratin5CrePtenflox/flox  •  k5CreTg Ptenflox/flox  •  Keratin5Cre Ptenflox/flox

Description

Mice homozygous for a conditional targeted mutation of Pten, and carrying a Cre transgene controlled by the human keratin 5 promoter/enhancer. The genetic background was a mix of C57BL/6J and 129P2/OlaHsd.

Strain Genetics

Tg(KRT5-cre)1Tak

Models

7 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin - Epidermis carcinoma Skin - Epidermis

very high

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81

Skin - Epidermis hyperplasia Skin - Epidermis

100

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81

Skin - Epidermis papilloma Skin - Epidermis

100

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81

Skin gland - Sebaceous gland carcinoma Skin gland - Sebaceous gland

11

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81

Skin gland - Sweat gland adenocarcinoma Skin gland - Sweat gland

11

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81

Skin papilloma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

100

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81

Skin papilloma Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)

0

References: Suzuki A, Cancer Res 2003 Feb 1;63(3):674-81