Strain SummaryFVB/N-Tg(EmuSR-tTa)83Bop Tg(tetO-MYC)36aBop

Strain Name

FVB/N-Tg(EmuSR-tTa)83Bop Tg(tetO-MYC)36aBop

Strain Type(s)

transgenic

Strain Synonym(s)

EμSRα MYC  •  EμSR-tTA/tet-o-MYC  •  FVB/N-Tg(EmuSR-tTa)83Bop Tg(tetO-MYC)36Bop  •  FVB/N-Tg(EmuSR-tTa)83Bop Tg(tTA-MYC)36Bop

Description

Double transgenic mice that conditionally overexpress human MYC in hematopoietic cells in absence of doxycycline. Transgenic founders were derived in FVB/N.

Strain Genetics

Tg(EmuSR-tTa)83Bop
Tg(EmuSR-tTa)83Bop
Tg(tetO-MYC)36aBop

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Bone osteosarcoma Bone

1

References: Jain M, Science 2002 Jul 5;297(5578):102-4

Leukocyte - Lymphocyte - T-lymphocyte lymphoma Leukocyte - Lymphocyte - T-lymphocyte

very high

References: Felsher DW, Mol Cell 1999 Aug;4(2):199-207

Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte doxycycline

0

References: Felsher DW, Mol Cell 1999 Aug;4(2):199-207

Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

100

References: Felsher DW, Mol Cell 1999 Aug;4(2):199-207

Leukocyte - Myelocyte (Granulocyte) leukemia Leukocyte - Myelocyte (Granulocyte)

high

References: Felsher DW, Mol Cell 1999 Aug;4(2):199-207