Strain Summary129S4/SvJae-Krastm3Tyj/+

Strain Name

129S4/SvJae-Krastm3Tyj/+

Strain Type(s)

targeted mutation (knock-in)

Strain Synonym(s)

129S2/SvPas-Kras2tm3Tyj/+  •  K-ras LA2.129/sv  •  K-rasLA2;129/sv

Description

Mice heterozygous for a targeted mutation of Kras. Spontaneous somatic recombination leads to the expression of an activated oncogenic KRAS protein. The genetic background was 129S4/SvJae.

Strain Genetics

Krastm3Tyj / Kras+

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine - Large Intestine - Colon foci - aberrant crypt (ACF) Intestine - Large Intestine - Colon

100

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Leukocyte - Lymphocyte lymphoma Thymus

27

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Lung - Alveolus adenocarcinoma Lung - Alveolus

100

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Sites of Metastasis: Kidney , Lymph node

Skin fibropapilloma Skin

observed

References: Bronson RT, Personal Communication 2004;():

6 pathology image(s)

Skin papilloma Skin

37

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6