Strain SummaryB6;129S4-Krastm3Tyj/+

Strain Name

B6;129S4-Krastm3Tyj/+

Strain Type(s)

targeted mutation (knock-in)

Strain Synonym(s)

B6;129S2-Kras2tm3Tyj/+  •  K-rasLA2  •  K-rasLA2C57Bl6/129/sv F1  •  KrasLA  •  KrasLA2  •  K-rasLA2;F1

Description

Heterozygous mice. The genetic background of these mice was 50% C57BL/6 and 50% 129S4/SvJae. [They were reported to be F1 but the direction of the cross was not given.]

Strain Genetics

Krastm3Tyj / Kras+

Models

11 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine - Large Intestine - Colon carcinoma Intestine - Large Intestine - Colon

0

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Intestine - Large Intestine - Colon foci - aberrant crypt (ACF) Intestine - Large Intestine - Colon

100

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Leukocyte - Lymphocyte lymphoma Thymus

44

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Lung - Alveolus adenocarcinoma Lung - Alveolus

0 - 100

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Sites of Metastasis: Kidney , Lymph node

Lung - Alveolus hyperplasia - adenomatous Lung - Alveolus

observed

References: Bronson RT, Personal Communication 2004;():

3 pathology image(s)

Lung adenocarcinoma Lung

observed

References: Sweet-Cordero A, Nat Genet 2005 Jan;37(1):48-55

Lung adenoma Lung

100

References: Sweet-Cordero A, Nat Genet 2005 Jan;37(1):48-55

Lung normal tissue (control) Lung

not applicable

References: Sweet-Cordero A, Nat Genet 2005 Jan;37(1):48-55

Lung tumor Lung

observed

References: Sweet-Cordero A, Nat Genet 2005 Jan;37(1):48-55

1 pathology image(s)

Pancreas carcinoma Pancreas

0

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6

Skin papilloma Skin

16

References: Johnson L, Nature 2001 Apr 26;410(6832):1111-6