Strain SummaryC57BL/6 +/+ : 129S2/SvPas-Nf1tm1Tyj/Nf1tm2Tyj

Strain Name

C57BL/6 +/+ : 129S2/SvPas-Nf1tm1Tyj/Nf1tm2Tyj

Strain Type(s)

chimeric  •  targeted mutation (knockout)

Strain Synonym(s)

C57BL/6 +/+ : 129S2/SvPas-Nf1tm1Tyj/tm2Tyj  •  Nf1-/-:Nf1+/+ chimera


Chimeric mice generated by injection of doubly-targeted embryonal stem (ES) cells into C57BL/6 blastocysts.

Strain Genetics

Nf1tm1Tyj / Nf1tm2Tyj


1 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
PNS - Schwann cell neurofibroma - plexiform PNS - Nerve sheath


References: Cichowski K, Science 1999 Dec 10;286(5447):2172-6