Strain SummaryB6.129P2-Apctm1Rak/+

Strain Name

B6.129P2-Apctm1Rak/+

Strain Type(s)

congenic  •  targeted mutation (knockout)

Strain Synonym(s)

C57BL/6J-Apctm1Rak/+  •  C57BL6/J-Apc+/Apc1638N  •  Apc1638 heterozygotes  •  Apc1638N

Description

Heterozygous mice. The genetic background of these mice was congenic C57BL/6J. ES-cells of a 129P2/OlaHsd genetic background were used to generate the mutant allele.

Strain Genetics

Apctm1Rak / Apc+

Models

21 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Connective tissue - Fibroblast fibroma - ossifying Oral cavity

7.1

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Gastrointestinal tract adenoma Gastrointestinal tract Western style

35 - 46

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Gastrointestinal tract adenoma Gastrointestinal tract

44 - 50

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Gastrointestinal tract carcinoma Gastrointestinal tract Western style

23 - 65

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Gastrointestinal tract carcinoma Gastrointestinal tract

6.3 - 13

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Gastrointestinal tract dysplasia Gastrointestinal tract Western style

38 - 53

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Gastrointestinal tract dysplasia Gastrointestinal tract

19 - 31

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

6.7

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

27

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Large Intestine - Colon foci - aberrant crypt (ACF) Intestine - Large Intestine - Colon

observed

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Large Intestine - Colon foci - aberrant crypt (ACF) Intestine - Large Intestine - Colon 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

observed

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Large Intestine - Colon hyperplasia Intestine - Large Intestine - Colon Western style

69 - 88

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Intestine - Large Intestine - Colon hyperplasia Intestine - Large Intestine - Colon

44 - 56

References: Yang K, Cancer Res 1998 Dec 15;58(24):5713-7

Intestine - Small Intestine adenocarcinoma Intestine - Small Intestine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Small Intestine adenoma Intestine - Small Intestine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Small Intestine tumor Intestine - Small Intestine

observed

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Intestine - Small Intestine tumor Intestine - Small Intestine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

observed

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Mammary gland adenocarcinoma Mammary gland

7.1

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Mammary gland adenocarcinoma - squamous Mammary gland 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

14

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Skin squamous cell carcinoma Skin 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

7.1

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81

Spleen hyperplasia Spleen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

7.1

observed

References: Sorensen IK, Carcinogenesis 1997 Apr;18(4):777-81