Strain SummaryB6;129S-Nf1tm1Tyj/+

Strain Name

B6;129S-Nf1tm1Tyj/+

Strain Type(s)

targeted mutation (knockout)

Strain Synonym(s)

B6,129-Nf1tm1Tyj/+  •  Nf1 heterozygote  •  Nf1+/n31  •  Nf1+/-  •  Nf1+/Nf1n31  •  Nf1n31  •  Nf-1 +/n31

Description

Heterozygous mice. The genetic background of this strain is a mixture of C57BL/6, 129S2/SvPas, and 129S4/SvJae.

Strain Genetics

Nf1tm1Tyj / Nf1+

Models

14 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

observed

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Adrenal gland tumor Adrenal gland

18 - 22.5

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

CNS - Brain - Optic chiasma glioma CNS - Brain - Optic chiasma

0

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Connective tissue - Fibroblast fibrosarcoma Connective tissue - Fibroblast

4.8 - 7.5

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

3.2

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

observed

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Leukocyte leukemia Leukocyte

7.5 - 35

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Leukocyte lymphoma Leukocyte

observed - 35

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Liver carcinoma Liver

5.9

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Liver hepatoma Liver

6.5 - 7.5

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Lung adenocarcinoma Lung

observed - 20

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

5

References: Cichowski K, Science 1999 Dec 10;286(5447):2172-6

PNS - Schwann cell neurofibroma PNS - Nerve sheath

0

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61

PNS - Schwann cell neurofibrosarcoma PNS - Nerve sheath

2.5

References: Jacks T, Nat Genet 1994 Jul;7(3):353-61