Strain SummaryC57BL/6-Apctm2Rak Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy Tg(tetO-Kras*G12D)#Rdp Tg(Vil1-cre/ERT2)23Syr Trp53tm1Brn/+

Strain Name

C57BL/6-Apctm2Rak Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy Tg(tetO-Kras*G12D)#Rdp Tg(Vil1-cre/ERT2)23Syr Trp53tm1Brn/+

Strain Type(s)

gene trapped  •  targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

C57BL/6-Apctm2Rak Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy Tg(tetO-Kras*G12D)#Rdp Tg(Vil-cre/ERT2)23Syr Trp53tm1Brn/+  •  IKA(P/+)

Description

Compound mutant mice. Mice were backcrossed to C57BL/6 an unknown number of times and had contribution from FVB/N, DBA/2, C57BL/6J, SJL, 129/Sv, 129X1/SvJ, 129S1/Sv, and 129P2/OlaHsd.

Strain Genetics

Tg(Vil1-cre/ERT2)23Syr
Tg(tetO-Kras*G12D)#Rdp
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy
Trp53tm1Brn / Trp53+
Tg(Vil1-cre/ERT2)23Syr
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy

Models

5 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Intestine - Large Intestine adenoma Intestine - Large Intestine 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)   ⋅   doxycycline

64

References: Boutin AT, Genes Dev 2017 Feb 15;31(4):370-382

Intestine - Large Intestine tumor Intestine - Large Intestine 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)   ⋅   doxycycline

72.73

References: Boutin AT, Genes Dev 2017 Feb 15;31(4):370-382

Sites of Metastasis: (Unspecified organ)

Intestine - Small Intestine tumor Intestine - Small Intestine 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)   ⋅   doxycycline

0

References: Boutin AT, Genes Dev 2017 Feb 15;31(4):370-382

Intestine adenocarcinoma Intestine 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)   ⋅   doxycycline

9

References: Boutin AT, Genes Dev 2017 Feb 15;31(4):370-382

Intestine tumor Intestine 4-hydroxytamoxifen (4-OHT) (for inducing expression from mutant alleles)   ⋅   doxycycline

observed - 72.73

References: Boutin AT, Genes Dev 2017 Feb 15;31(4):370-382