Strain SummaryC57BL/6-Krastm4Tyj/+ Smad4tm2.1Cxd Tg(Krt1-15-cre/PGR)22Cot

Strain Name

C57BL/6-Krastm4Tyj/+ Smad4tm2.1Cxd Tg(Krt1-15-cre/PGR)22Cot

Strain Type(s)

targeted mutation (conditional)  •  transgenic

Strain Synonym(s)

K15.KrasG12D.Smad4-/-

Description

Heterozygous Kras, homozygous Smad4 mice carrying the Tg(Krt1-15-cre/PGR)22Cot transgene on a C57BL/6 background with possible contributions from C57BL/6J, SJL/J, 129S6/SvEvTac, and/or 129S4/SvJae.

Strain Genetics

Tg(Krt1-15-cre/PGR)22Cot
Krastm4Tyj / Kras+
Tg(Krt1-15-cre/PGR)22Cot

Models

14 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Skin - Dorsal region carcinoma - spindle cell Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region dysplasia - squamous Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region papilloma Skin - Dorsal region RU-486

very low

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region squamous cell carcinoma Skin - Dorsal region RU-486

100

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Sites of Metastasis: Lung , Lymph node

Skin - Dorsal region squamous cell carcinoma Skin - Head RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region squamous cell carcinoma Neck RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region squamous cell carcinoma - moderately differentiated Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region squamous cell carcinoma - well differentiated Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Dorsal region tumor Skin - Dorsal region RU-486

100

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Sites of Metastasis: Lung , Lymph node

Skin - Dorsal region tumor - epidermoid Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Hair follicle - Basal cell carcinoma Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin - Hair follicle - Basal cell squamous cell carcinoma Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Sites of Metastasis: Lung

Skin - Hair follicle - Basal cell trichoepithelioma Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404

Skin gland - Sebaceous gland adenoma - sebaceous Skin - Dorsal region RU-486

observed

References: White RA, J Clin Invest 2013 Oct 1;123(10):4390-404