Strain SummaryC57BL/6-Col4a3tm1Dec Thbs1tm1Hyn Trp53tm1Brd

Strain Name

C57BL/6-Col4a3tm1Dec Thbs1tm1Hyn Trp53tm1Brd

Strain Type(s)

targeted mutation (knockout)

Strain Synonym(s)

p53-/-/Tum-/-/TSP1,sup>-/-

Description

Homozygous Col4a3, Trp53, Thbs1 mutant mice on a C57BL/6 background with possible contributions from 129X1/SvJ, 129S2/SvPas, and/or 129S7/SvEvBrd-Hprt+.

Models

4 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Leukocyte lymphoma Leukocyte

observed - 41.7

References: Xie L, Proc Natl Acad Sci U S A 2011 Jun 14;108(24):9939-44

Mesodermal cell/mesoblast sarcoma Mesodermal cell/mesoblast

4.165

References: Xie L, Proc Natl Acad Sci U S A 2011 Jun 14;108(24):9939-44

(Unspecified organ) angiosarcoma (Unspecified organ)

observed

References: Xie L, Proc Natl Acad Sci U S A 2011 Jun 14;108(24):9939-44

(Unspecified organ) tumor (Unspecified organ)

50

References: Xie L, Proc Natl Acad Sci U S A 2011 Jun 14;108(24):9939-44