Strain SummaryC3H/He

Strain Name

C3H/He

Strain Type(s)

inbred

Strain Synonym(s)

C3H  •  C3H Heston  •  C3H/Heston

Models

40 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adrenal gland - Subcapsular cell hyperplasia Adrenal gland - Cortex

100

100

References: Kim JS, Exp Anim 1997 Oct;46(4):303-6

Blood vessel hemangioendothelioma Blood vessel

0.9

References: Heston WE, J Natl Cancer Inst 1964 Jan;32():237-51

Eye - Harderian gland tumor Eye - Harderian gland

1

References: Murphy ED, 1966;():521-62

Liver - Hepatocyte foci - basophilic Liver - Hepatocyte

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver - Hepatocyte foci - basophilic Liver - Hepatocyte N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver - Hepatocyte foci - basophilic Liver - Hepatocyte phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver - Hepatocyte foci - eosinophilic Liver - Hepatocyte phenobarbital (PB)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver - Hepatocyte foci - eosinophilic Liver - Hepatocyte N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver - Hepatocyte foci - eosinophilic Liver - Hepatocyte phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatocellular adenoma Liver

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatocellular adenoma Liver phenobarbital (PB)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatocellular adenoma Liver N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatocellular adenoma Liver phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatocellular carcinoma Liver

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatocellular carcinoma Liver N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Sites of Metastasis: Lung

Liver hepatocellular carcinoma Liver phenobarbital (PB)   ⋅   N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Wastl UM, Mol Carcinog 1998 Aug;22(4):229-34

Liver hepatoma Liver urethane (ethyl carbamate)

79.5 - 92.6

References: Heston WE, J Natl Cancer Inst 1960;24():425-435

Liver hepatoma Liver

0

85 - 85.3

observed - 85

References: Heston WE, Int J Cancer 1971 Jan 15;7(1):141-8   ⋅   Heston WE, J Natl Cancer Inst 1960;24():425-435   ⋅   Heston WE, J Natl Cancer Inst 1964 Jan;32():237-51   ⋅   Murphy ED, 1966;():521-62   ⋅   Staats J, Cancer Res 1985 Mar;45(3):945-77   ⋅   Staats J, Companion to Mouse News Lett No. 21 1959;():

Liver tumor Liver N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Kalkuhl A, Hepatology 1998 Apr;27(4):1081-8

Liver tumor Liver 7,12-dimethylbenz[a]anthracene (DMBA)

observed

References: Kalkuhl A, Hepatology 1998 Apr;27(4):1081-8

Liver tumor - basophilic Liver

observed

References: Rumsby PC, Carcinogenesis 1991 Dec;12(12):2331-6

Liver tumor - basophilic Liver N-diethylnitrosamine (N,N-diethylnitrosamine) (N-nitrosodiethylamine) (NDEA) (diethylnitrosamine) (DEN)

observed

References: Rumsby PC, Carcinogenesis 1991 Dec;12(12):2331-6

Liver tumor - eosinophilic Liver phenobarbitone (PB)

observed

References: Rumsby PC, Carcinogenesis 1991 Dec;12(12):2331-6

Lung tumor Lung urethane (ethyl carbamate)

62.1 - 100

References: Heston WE, J Natl Cancer Inst 1960;24():425-435

Lung tumor Lung

0.9

7.8

References: Heston WE, J Natl Cancer Inst 1960;24():425-435   ⋅   Heston WE, J Natl Cancer Inst 1964 Jan;32():237-51

Mammary gland adenocarcinoma Mammary gland

88

References: Sugino T, Int J Cancer 1993 Aug 19;55(1):141-7

Sites of Metastasis: Lung

Mammary gland adenocarcinoma Mammary gland MMTV - mouse mammary tumor virus

100

References: Heston WE, J Natl Cancer Inst 1964 Jan;32():237-51

Mammary gland hyperplasia - alveolar Mammary gland MMTV - mouse mammary tumor virus

25 - 94

References: Heston WE, Int J Cancer 1971 Jan 15;7(1):141-8

Mammary gland tumor Mammary gland

90 - 100

high - 100

References: Deringer MK, J Natl Cancer Inst 1962;28():203-210   ⋅   Murphy ED, 1966;():521-62   ⋅   Staats J, Cancer Res 1985 Mar;45(3):945-77   ⋅   Staats J, Companion to Mouse News Lett No. 21 1959;():   ⋅   Staats J, Companion to Mouse News Lett No. 25 1961;():

Mammary gland tumor Mammary gland MMTV - mouse mammary tumor virus

observed - 99

observed - 90

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Deringer MK, J Natl Cancer Inst 1959;22():995-1002   ⋅   Festing MFW, Mouse Genome 1996;94(3):523-677   ⋅   Heston WE, Int J Cancer 1971 Jan 15;7(1):141-8   ⋅   Heston WE, J Natl Cancer Inst 1964 Jan;32():237-51   ⋅   Nusse R, Cell 1982 Nov;31(1):99-109

Skin tumor Skin 3-methylcholanthrene (MCA) (3-MC)

62

References: Whitmire CE, J Natl Cancer Inst 1971 Dec;47(6):1255-65

Urinary bladder carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

0 - 82

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder carcinoma Urinary bladder

0

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder dysplasia Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

observed - 100

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder hyperplasia Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

100

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder hyperplasia - nodular Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

55 - 100

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder metaplasia - squamous Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

9.1

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder squamous cell carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

9.1 - 50

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

Urinary bladder transitional cell carcinoma Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)

73

References: Elkin M, Carcinogenesis 1998 Dec;19(12):2095-9

(Unspecified organ) reticulum cell neoplasm (Unspecified organ)

1.0

References: Heston WE, J Natl Cancer Inst 1960;24():425-435