Strain SummaryC3H/HeJ

Strain Name

C3H/HeJ

Strain Type(s)

inbred

Strain Synonym(s)

C3  •  C3H  •  C3H/He  •  C3H/HeJ, H-2k  •  C3H/HeJ MMTV-  •  C3H/HeJ mtv+  •  C3H/HeJ-MTV+  •  C3H Heston  •  C3H The Jackson Laboratory  •  MTV+

Models

330 unique models displayed. A model is a set of tumors that share the same tumor name, organ(s) affected, and treatment type for a specific strain.
Frequency
Model Name Organ Affected Tumor Inducing Agent(s) Female Male Mixed Pop. Unspecified Additional Information Model Details
Adipose tissue - White lipoma Adipose tissue - White

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Adipose tissue lipoma Peritoneal cavity

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Adipose tissue lipoma - pedunculated Adipose tissue

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Adrenal gland - Cortex adenoma Adrenal gland - Cortex

0

observed - high

References: Sundberg J, MGI Direct Data Submission 2007;():   ⋅   Sundberg J, Personal Communication 1997;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

13 pathology image(s)

Adrenal gland - Medulla hyperplasia Adrenal gland - Medulla MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Adrenal gland - Medulla hyperplasia Adrenal gland - Medulla 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Adrenal gland - Medulla hyperplasia Adrenal gland - Medulla MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Adrenal gland - Medulla pheochromocytoma Adrenal gland - Medulla 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Adrenal gland - Subcapsular cell hyperplasia - spindle cell Adrenal gland - Subcapsular cell

high

moderate

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Adrenal gland hyperplasia - nodular Adrenal gland

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Adrenal gland hyperplasia - spindle cell Adrenal gland

observed

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Adrenal gland tumor - carcinoid Adrenal gland

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Blood vessel hemangioma Lymph node

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Blood vessel hemangioma Blood vessel

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Blood vessel hemangioma Uterus

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Blood vessel hemangiosarcoma Blood vessel

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Blood vessel hemangiosarcoma Liver

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Blood vessel hemangiosarcoma Muscle - Striated - Skeletal

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Bone - Skull osteosarcoma Bone - Skull 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed - 2.86

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Bone - Skull osteosarcoma Bone - Skull MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed - 3.12

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Bone - Sternum hyperplasia Bone - Sternum MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Bone - Sternum osteosarcoma Lung MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Sites of Metastasis: Bone - Sternum

Bone hyperplasia Bone

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Bone hyperplasia Bone MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Bone hyperplasia Bone MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

2.63 - 82

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Bone hyperplasia Bone 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 82

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Bone lesion - fibro-osseous Bone

0 - 7.69

0

0 - 5.56

References: Berndt A, Exp Mol Pathol 2015 Nov 14;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Bone osteosarcoma Bone MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Bone osteosarcoma Bone 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

CNS - Brain normal tissue (control) CNS - Brain

not applicable

References: Sundberg J, Personal Communication 1997;():

4 pathology image(s)

Epididymis cyst Epididymis

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Erythrocyte leukemia - erythroleukemia Spleen

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Erythrocyte neoplasm Erythrocyte

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Esophagus hyperplasia Esophagus

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Eye - Harderian gland adenocarcinoma Eye - Harderian gland

0.3

References: Sheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Eye - Harderian gland adenoma - acinar Eye - Harderian gland

1.4

References: Sheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Eye - Harderian gland adenoma - cystic Eye - Harderian gland

0.3

References: Sheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Eye - Harderian gland adenoma - cystic papillary Eye - Harderian gland

0.3

References: Sheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Eye - Harderian gland adenoma - papillary Eye - Harderian gland

1.4

References: Sheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Eye - Harderian gland tumor Eye - Harderian gland

3.8

References: Sheldon WG, J Natl Cancer Inst 1983 Jul;71(1):61-8

Forestomach hyperplasia - papillary Forestomach

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Forestomach papilloma Forestomach

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Gallbladder cyst Gallbladder

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Gallbladder hyperplasia Gallbladder

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Gallbladder hyperplasia - papillary Gallbladder

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Large Intestine - Cecum hyperplasia Intestine - Large Intestine - Cecum dextran sulfate sodium (DSS)

observed

References: Mahler M, Am J Physiol 1998 Mar;274(3 Pt 1):G544-51

Intestine - Large Intestine - Cecum hyperplasia Intestine - Large Intestine - Cecum

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Large Intestine - Colon adenocarcinoma Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

0

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

observed

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Large Intestine - Colon dysplasia - high grade Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

0

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Large Intestine - Colon dysplasia - low grade Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

observed

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Large Intestine - Colon hyperplasia Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)

observed

observed

References: Mahler M, Am J Physiol 1998 Mar;274(3 Pt 1):G544-51

Intestine - Large Intestine - Colon lesion Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

observed

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

observed - 100

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Large Intestine - Rectum tumor Intestine - Large Intestine - Rectum 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Intestine - Large Intestine tumor Intestine - Large Intestine dextran sulfate sodium (DSS)   ⋅   azoxymethane (AOM)

100

References: Van Der Kraak L, Mamm Genome 2016 Jun;27(5-6):213-24

Intestine - Small Intestine - Brunner's gland adenoma Intestine - Small Intestine - Brunner's gland

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Small Intestine - Brunner's gland hyperplasia Intestine - Small Intestine - Brunner's gland

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

0

0 - observed

References: Sundberg J, MGI Direct Data Submission 2007;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

3 pathology image(s)

Intestine - Small Intestine - Duodenum cyst Intestine - Small Intestine - Duodenum

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Small Intestine - Duodenum hyperplasia Intestine - Small Intestine - Duodenum

0

0 - observed

References: Sundberg J, MGI Direct Data Submission 2007;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

2 pathology image(s)

Intestine - Small Intestine - Duodenum polyp Intestine - Small Intestine - Duodenum

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Small Intestine - Ileum polyp Intestine - Small Intestine - Ileum

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Small Intestine - Jejunum hyperplasia Intestine - Small Intestine - Jejunum

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Intestine - Small Intestine - Jejunum polyp Intestine - Small Intestine - Jejunum

0

observed - low

References: Sundberg J, MGI Direct Data Submission 2007;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

2 pathology image(s)

Intestine - Small Intestine normal tissue (control) Intestine - Small Intestine

not applicable

References: Sundberg J, Personal Communication 1997;():

3 pathology image(s)

Kidney adenoma Kidney

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Kidney cyst Kidney

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell tumor Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Lymphocyte leukemia - lymphocytic Leukocyte - Lymphocyte

0

0

References: Hoag WG, Ann N Y Acad Sci 1963 Nov 4;108():805-831

Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)

9.09

References: Fenske TS, Cancer Res 2006 May 15;66(10):5029-38

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Leukocyte - Monocyte - Macrophage - Histiocyte

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Monocyte - Macrophage - Histiocyte histiocytic sarcoma Spleen

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Eye - Eyelid

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Lymph node

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell tumor Skin

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Myelocyte (Granulocyte) hyperplasia Bone marrow

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Leukocyte - Myelocyte (Granulocyte) tumor - malignant Leukocyte - Myelocyte (Granulocyte) N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)

0

References: Fenske TS, Cancer Res 2006 May 15;66(10):5029-38

Leukocyte leukemia Leukocyte Friend leukemia virus - "regressing" (RFV)

40 - 100

References: Dietz M, Int J Cancer 1972 Jul 15;10(1):99-104

Leukocyte leukemia Leukocyte Friend leukemia virus - "conventional" (CFV)

82 - 90

References: Dietz M, Int J Cancer 1972 Jul 15;10(1):99-104

Leukocyte lymphoma Leukocyte

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Liver - Bile duct adenoma Liver - Bile duct

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Liver - Bile duct hyperplasia Liver - Bile duct

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Liver adenoma Liver 2-acetylaminofluorene (AAF)

observed

References: Wang Y, Cancer Res 1993 Apr 1;53(7):1620-4

Liver foci - acidophilic Liver

observed

References: Mikaelian I, Personal Communication 2004;():

2 pathology image(s)

Liver hepatocellular adenoma Liver

observed

References: Mikaelian I, Personal Communication 2004;():

4 pathology image(s)

Liver hepatocellular adenoma Liver diethylnitrosamine (DEN)

observed

References: Graveel CR, Oncogene 2003 Mar 20;22(11):1730-6

Liver hepatocellular adenoma Liver MMTV - mouse mammary tumor virus   ⋅   corn oil

1.24

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Liver hepatocellular adenoma Liver MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

1.54

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Liver hepatocellular adenoma Liver 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

1.4

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Liver hepatocellular carcinoma Liver

observed

References: Mikaelian I, Personal Communication 2004;():

3 pathology image(s)

Liver hepatocellular carcinoma Liver diethylnitrosamine (DEN)

observed

References: Graveel CR, Oncogene 2003 Mar 20;22(11):1730-6

Liver hepatocellular carcinoma Liver MMTV - mouse mammary tumor virus   ⋅   corn oil

1.65

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Liver hepatocellular carcinoma Liver MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

.92

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Liver hepatocellular carcinoma Liver 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

1.4

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Liver hepatocellular tumor Liver diethylnitrosamine (DEN)

observed

References: Graveel CR, Oncogene 2003 Mar 20;22(11):1730-6

Liver hepatoma Liver

0

0 - 21

References: Staats J, Cancer Res 1985 Mar;45(3):945-77   ⋅   Staats J, Companion to Mouse News Lett No. 25 1961;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Liver preneoplastic lesion Liver diethylnitrosamine (DEN)

observed

References: Graveel CR, Oncogene 2003 Mar 20;22(11):1730-6

Liver tumor Liver

observed

60

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Davis LM, Carcinogenesis 1994 Aug;15(8):1637-45   ⋅   Devereux TR, Carcinogenesis 1991 Feb;12(2):299-303

Liver tumor Liver 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

observed

References: Devereux TR, Carcinogenesis 1991 Feb;12(2):299-303

Liver tumor Liver N-nitrosodimethylamine (NDMA)

observed

References: Devereux TR, Carcinogenesis 1991 Feb;12(2):299-303

Liver tumor Liver diethylnitrosamine (DEN)

observed

References: Graveel CR, Oncogene 2003 Mar 20;22(11):1730-6

Lung adenoma Lung 2-acetylaminofluorene (AAF)

observed

References: Wang Y, Cancer Res 1993 Apr 1;53(7):1620-4

Lung adenoma Lung urethane (ethyl carbamate)

6.7

References: Malkinson AM, J Natl Cancer Inst 1983 May;70(5):931-6

Lung adenoma Lung dimethylnitrosamine (DMN)

10

References: Chen B, Carcinogenesis 1994 Sep;15(9):2031-5

Lung adenoma Lung

0

0

0

References: Berndt A, Cancer Res 2011 Sep 1;71(17):5779-91   ⋅   Chen B, Carcinogenesis 1994 Sep;15(9):2031-5   ⋅   Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Lung adenoma Lung mainstream cigarette smoke (MCS)

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung adenoma Lung N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)

observed

References: Fenske TS, Cancer Res 2006 May 15;66(10):5029-38

Lung carcinoma Lung mainstream cigarette smoke (MCS)

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung carcinoma Lung

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung carcinoma Lung N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)

0

References: Fenske TS, Cancer Res 2006 May 15;66(10):5029-38

Lung hyperplasia Lung

0 - observed

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Lung hyperplasia Lung mainstream cigarette smoke (MCS)

observed

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung papilloma Lung

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung papilloma Lung mainstream cigarette smoke (MCS)

0

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lung tumor Lung

0 - 1

1 - 25

5.0 - 10.0

References: Devereux TR, Carcinogenesis 1991 Feb;12(2):299-303   ⋅   Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20   ⋅   Hoag WG, Ann N Y Acad Sci 1963 Nov 4;108():805-831   ⋅   Ryan J, J Natl Cancer Inst 1987 Dec;79(6):1351-7   ⋅   You M, Proc Natl Acad Sci U S A 1992 Jul 1;89(13):5804-8

Lung tumor Lung vinyl carbamate (VC)

observed

References: You M, Proc Natl Acad Sci U S A 1992 Jul 1;89(13):5804-8

Lung tumor Lung 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

97

References: Devereux TR, Carcinogenesis 1991 Feb;12(2):299-303

Lung tumor Lung N-nitrosodimethylamine (NDMA)

97

References: Devereux TR, Carcinogenesis 1991 Feb;12(2):299-303

Lung tumor Lung urethane (ethyl carbamate)

7

References: Chen B, Proc Natl Acad Sci U S A 1994 Feb 15;91(4):1589-93

Lung tumor Lung mainstream cigarette smoke (MCS)

0 - observed

References: Gordon T, Cancer Lett 2009 Mar 18;275(2):213-20

Lymph node cyst Lymph node

0

0 - observed

References: Sundberg J, MGI Direct Data Submission 2007;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Lymph node hyperplasia Reticulocyte

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mammary gland adenocarcinoma Mammary gland

observed - 95

1

References: Hoag WG, Ann N Y Acad Sci 1963 Nov 4;108():805-831   ⋅   Mikaelian I, Personal Communication 2002;():   ⋅   Mikaelian I, Personal Communication 2004;():

Sites of Metastasis: Lung

37 pathology image(s)

Mammary gland adenocarcinoma Mammary gland MMTV - mouse mammary tumor virus   ⋅   corn oil

4.26 - 44.83

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - 100

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 58.33

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - acinar Mammary gland

observed

References: Mikaelian I, Personal Communication 2004;():

12 pathology image(s)

Mammary gland adenocarcinoma - microacinar Mammary gland MMTV - mouse mammary tumor virus

observed

References: Mikaelian I, Breast Cancer Res 2004;6(6):R668-79

Mammary gland adenocarcinoma - mixed Mammary gland

observed

References: Mikaelian I, Personal Communication 2004;():

9 pathology image(s)

Mammary gland adenocarcinoma - papillary Mammary gland

observed

References: Mikaelian I, Personal Communication 2004;():

2 pathology image(s)

Mammary gland adenocarcinoma - papillary Mammary gland MMTV - mouse mammary tumor virus

observed

References: Mikaelian I, Breast Cancer Res 2004;6(6):R668-79

Mammary gland adenocarcinoma - tubular Mammary gland

observed

References: Mikaelian I, Personal Communication 2004;():

4 pathology image(s)

Mammary gland adenocarcinoma - tubulostromal Mammary gland

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

6 pathology image(s)

Mammary gland adenocarcinoma - type A Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type A Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type A Mammary gland MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type B Mammary gland MMTV - mouse mammary tumor virus

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

Mammary gland adenocarcinoma - type B Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type B Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type B Mammary gland MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type C Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type C Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

very low

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type C Mammary gland MMTV - mouse mammary tumor virus   ⋅   corn oil

very low

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland adenocarcinoma - type P Mammary gland MMTV - mouse mammary tumor virus

observed

References: Mikaelian I, Breast Cancer Res 2004;6(6):R668-79

Mammary gland carcinoma - mixed Mammary gland

observed

References: Mikaelian I, Personal Communication 2004;():

1 pathology image(s)

Mammary gland foci Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland foci Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland hyperplasia - alveolar Mammary gland MMTV - mouse mammary tumor virus

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

Mammary gland hyperplasia - alveolar Mammary gland MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 12

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland hyperplasia - alveolar Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - 75

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland hyperplasia - alveolar Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 35.29

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland lesion Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland lesion Mammary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mammary gland tumor Mammary gland MMTV - mouse mammary tumor virus

observed - 100

References: Bradlow HL, Proc Natl Acad Sci U S A 1985 Sep;82(18):6295-9   ⋅   Brayton CF, Vet Pathol 2012 Jan;49(1):85-105   ⋅   Staats J, Companion to Mouse News Lett No. 25 1961;():

Mammary gland tumor Mammary gland

observed

7 - 100.0

References: Staats J, Cancer Res 1985 Mar;45(3):945-77

Mammary gland tumor Mammary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed - 53.85

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mesodermal cell/mesoblast myxosarcoma Muscle - Striated - Skeletal

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mesodermal cell/mesoblast sarcoma Peritoneal cavity

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mesodermal cell/mesoblast sarcoma Seminal vesicle

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mesodermal cell/mesoblast sarcoma Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mesodermal cell/mesoblast sarcoma Urinary bladder

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mesodermal cell/mesoblast sarcoma - stromal Uterus - Endometrium - Stroma

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Mesothelium mesothelioma Uterus MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mesothelium mesothelioma Uterus MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mesothelium mesothelioma Uterus 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Mesothelium mesothelioma Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Sites of Metastasis: Lymph node

Mouth - Oral mucosa cyst Mouth - Oral mucosa

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Muscle - Smooth leiomyoma Vagina

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Muscle - Smooth leiomyosarcoma Intestine - Large Intestine - Cecum

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Muscle - Smooth leiomyosarcoma Muscle - Smooth

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Muscle - Striated - Skeletal neoplasm - cystic Muscle - Striated - Skeletal 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Muscle - Striated - Skeletal rhabdomyosarcoma Muscle - Striated - Skeletal

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Muscle - Striated - Skeletal rhabdomyosarcoma - pleomorphic Muscle - Striated - Skeletal

0

References: Sher RB, PLoS One 2011;6(8):e23498

Myoepithelial cell myoepithelioma Myoepithelial cell

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

5 pathology image(s)

Myoepithelial cell myoepithelioma Lung

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Myoepithelial cell myoepithelioma Mammary gland

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Nail squamous cell carcinoma Nail

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ovary - Follicle cyst - follicular Ovary - Follicle

very high

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ovary - Germ cell teratoma Ovary - Germ cell MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary - Germ cell teratoma Ovary - Germ cell MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary - Germ cell teratoma Ovary - Germ cell 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary - Granulosa cell tumor Ovary - Granulosa cell corn oil

3.4

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary - Granulosa cell tumor - granulosa cell Ovary - Granulosa cell

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ovary - Granulosa cell tumor - granulosa cell Ovary - Granulosa cell 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Ovary - Granulosa cell tumor - granulosa cell Ovary - Granulosa cell MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Ovary - Luteal cell tumor Ovary - Luteal cell

low

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ovary - Luteal cell tumor Ovary - Luteal cell 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Ovary - Luteal cell tumor Ovary - Luteal cell MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Ovary - Theca cell thecoma Ovary - Theca cell

observed

References: Mikaelian I, Personal Communication 2004;():

2 pathology image(s)

Ovary adenoma Ovary

0 - observed

References: Mikaelian I, Personal Communication 2004;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

2 pathology image(s)

Ovary adenoma - tubular Ovary MMTV - mouse mammary tumor virus   ⋅   corn oil

observed - 50

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary adenoma - tubular Ovary MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

20.83 - 100

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary adenoma - tubular Ovary 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 60

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary cyst Ovary

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

3 pathology image(s)

Ovary cyst Ovary 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Ovary cyst Ovary MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Ovary cyst - bursal Ovary

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ovary hyperplasia - epithelial Ovary

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ovary luteoma Ovary corn oil

3.0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Ovary tumor - tubulostromal Ovary

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

PNS - Nerve sheath tumor Ear

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

PNS - Nerve sheath tumor Skin

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Pancreas - Duct adenoma Pancreas - Duct

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Pancreas - Islet of Langerhans adenoma Pancreas - Islet of Langerhans 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Pancreas - Islet of Langerhans hyperplasia Pancreas - Islet of Langerhans

observed

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Pancreas normal tissue (control) Pancreas

not applicable

References: Sundberg J, Personal Communication 1997;():

8 pathology image(s)

Peritoneal cavity lesion - nodular Peritoneal cavity 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Pituitary gland adenoma Pituitary gland

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

5 pathology image(s)

Pituitary gland adenoma Pituitary gland MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Pituitary gland adenoma Pituitary gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Pituitary gland adenoma Pituitary gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Prostate gland - Anterior lobe adenocarcinoma Prostate gland - Anterior lobe

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin - Ear melanoma Skin - Ear skin graft

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

17 pathology image(s)

Skin - Epidermis - Basal cell carcinoma Skin - Epidermis - Basal cell

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin - Epidermis cyst - inclusion Skin - Epidermis

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin - Vibrissa squamous cell carcinoma in situ Skin - Vibrissa

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin choristoma Skin

observed

References: Mikaelian I, Personal Communication 2002;():

1 pathology image(s)

Skin gland - Sweat gland hyperplasia Ear - Outer ear - Ear canal

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin hyperplasia - epithelial Ear

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin hyperplasia - epithelial Eye - Eyelid

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Skin normal tissue (control) Skin

not applicable

References: Sundberg J, Personal Communication 1997;():

16 pathology image(s)

Skin squamous cell carcinoma Skin MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Skin squamous cell carcinoma Skin MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Skin squamous cell carcinoma Skin 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Skin tumor Skin 12-O-tetradecanoylphorbol-13-acetate (TPA)   ⋅   7,12-dimethylbenz[a]anthracene (DMBA)

67

References: Sundberg JP, Mol Carcinog 1997 SEP;20(1):19-32

Spleen hyperplasia Spleen

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Spleen normal tissue (control) Spleen

not applicable

References: Sundberg J, Personal Communication 1997;():

12 pathology image(s)

Stomach - Glandular adenoma Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Stomach - Glandular cyst Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Stomach - Glandular cyst - glandular Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Stomach - Glandular hyperplasia Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Stomach - Glandular hyperplasia - adenomatous Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Stomach - Glandular polyp Stomach - Glandular

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Stomach papilloma Stomach

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Testis - Leydig cell (Interstitial cell) cyst Testis - Leydig cell (Interstitial cell)

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Testis - Leydig cell (Interstitial cell) hyperplasia Testis - Leydig cell (Interstitial cell)

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Testis - Leydig cell (Interstitial cell) tumor Testis - Leydig cell (Interstitial cell)

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Thymus normal tissue (control) Thymus

not applicable

References: Sundberg J, Personal Communication 1997;():

6 pathology image(s)

Thyroid gland - Follicular cell cyst Thyroid gland - Follicular cell

observed

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Thyroid gland adenoma Thyroid gland

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

6 pathology image(s)

Thyroid gland carcinoma Thyroid gland MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Thyroid gland carcinoma Thyroid gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Thyroid gland carcinoma Thyroid gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Thyroid gland hyperplasia - cystic Thyroid gland

low

moderate

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ureter - Transitional cell hyperplasia Ureter - Transitional cell

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ureter hyperplasia Muscle - Smooth

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Ureter polyp Ureter

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Urinary bladder - Transitional cell atypia Urinary bladder - Transitional cell

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Urinary bladder cyst - glandular Urinary bladder MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Urinary bladder neoplasm - cystic Urinary bladder MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Urinary bladder papilloma Urinary bladder

0

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Uterus - Cervix adenocarcinoma Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix adenocarcinoma Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - 10.42

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix adenocarcinoma Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 6.25

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix adenocarcinoma Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Sites of Metastasis: Intestine - Large Intestine - Rectum , Ureter , Urethra , Urinary bladder , Uterus , Vagina

Uterus - Cervix atypia - glandular Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix cyst - glandular Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix cyst - papillary Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix lesion Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 36

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix lesion Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - 97.78

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix lesion Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

2.7 - 73.33

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix myoblastoma - granular cell Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix myoblastoma - granular cell Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix myoblastoma - granular cell Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix neoplasia Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix neoplasia - glandular Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix neoplasia - glandular Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix neoplasm - cystic Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Cervix squamous cell carcinoma Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix squamous cell carcinoma Uterus - Cervix MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix squamous cell carcinoma Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Cervix tumor Uterus - Cervix 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Sites of Metastasis: Muscle - Striated - Skeletal

Uterus - Endometrium carcinoma Uterus - Endometrium MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Endometrium carcinoma Uterus - Endometrium corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Endometrium carcinoma Uterus - Endometrium 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Endometrium hyperplasia Uterus - Endometrium MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Endometrium hyperplasia - cystic Uterus - Endometrium

0 - observed

References: Mikaelian I, Personal Communication 2004;():   ⋅   Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

1 pathology image(s)

Uterus - Endometrium polyp Uterus - Endometrium MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

1.39

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Endometrium polyp Uterus - Endometrium corn oil

3.85

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Endometrium polyp Uterus - Endometrium 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

1.59

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine gland cyst - glandular Uterus - Uterine gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine gland hyperplasia Uterus - Uterine gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine gland neoplasia Uterus - Uterine gland 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine gland neoplasia Uterus - Uterine gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine gland neoplasm - cystic Uterus - Uterine gland MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn adenoacanthoma Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine horn adenoacanthoma Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine horn adenoacanthoma Uterus - Uterine horn 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 2.08

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine horn adenocarcinoma Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine horn adenocarcinoma Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - 3.12

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine horn adenocarcinoma Uterus - Uterine horn 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 4.17

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30   ⋅   Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus - Uterine horn atypia Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn hyperplasia - glandular Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   corn oil

25.53

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn hyperplasia - glandular Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

15.62 - 100

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn hyperplasia - glandular Uterus - Uterine horn 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

24 - 95.83

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn lesion Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   corn oil

2.13

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn lesion Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

3.12 - 93

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn lesion Uterus - Uterine horn 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

5.56 - 81.25

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn neoplasia Uterus - Uterine horn 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn neoplasia Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn neoplasia - glandular Uterus - Uterine horn 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn neoplasia - glandular Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus - Uterine horn tumor Uterus - Uterine horn MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus adenocarcinoma Uterus MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus adenocarcinoma Uterus MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus adenocarcinoma Uterus 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus adenoma Uterus

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Uterus atypia Uterus 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Uterus fibropapilloma Uterus

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Uterus hyperplasia - glandular Uterus MMTV - mouse mammary tumor virus

observed

References: Brayton CF, Vet Pathol 2012 Jan;49(1):85-105

Uterus lesion - nodular Uterus 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Uterus preneoplastic lesion Uterus 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Vagina lesion Vagina MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

observed

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Vagina papilloma Vagina

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

Vagina polyp Vagina

observed

References: Sundberg J, MGI Direct Data Submission 2007;():

Vagina squamous cell carcinoma Vagina MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Vagina squamous cell carcinoma Vagina MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Vagina squamous cell carcinoma Vagina 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1980 Nov;4(5-6):81-95

Vulva squamous cell carcinoma Vulva

0

References: Sundberg JP, Pathobiol Aging Age Relat Dis 2011;1():

(Unspecified organ) tumor - malignant (Unspecified organ) MMTV - mouse mammary tumor virus   ⋅   corn oil

0

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

(Unspecified organ) tumor - malignant (Unspecified organ) MMTV - mouse mammary tumor virus   ⋅   diethylstilbestrol (DES)   ⋅   corn oil

6.25 - 12.5

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

(Unspecified organ) tumor - malignant (Unspecified organ) 17beta-estradiol (E2)   ⋅   MMTV - mouse mammary tumor virus   ⋅   corn oil

0 - 10.42

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

(Unspecified organ) tumor - malignant (Unspecified organ) diethylstilbestrol (DES)   ⋅   corn oil

0 - 10.81

References: Highman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30