Reference SummaryBeamer WG, Cancer Res 1988 Sep 15;48(18):5092-5

Title

Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone.

Authors

Beamer WG; Tennent BJ; Shultz KL; Nadeau JH; Shultz LD; Skow LC

Journal

Cancer Res

Volume

48

Issue

18

Year

1988

Pages

5092-5

Abstract

Spontaneous, malignant ovarian granulosa cell (GC) tumors occur in pubertal SWR and specific SWXJ recombinant inbred strains of mice. Treatment of these mice with dehydroepiandrosterone (DHEA), an adrenal secretory steroid with anticancer actions against spontaneous and carcinogen-induced tumors of different tissues, gave unexpected results. Diet supplemented with 0.4% DHEA (a) induced significantly more GC tumors in spontaneous tumor-susceptible strains (SWR and SWXJ-1, -4, and -9), (b) induced the first GC tumors observed in five previously tumor-free strains (SWXJ-6, -7, -8, -10, and -12), and (c) failed to induce GC tumors in SJL and in the remaining six SWXJ strains (SWXJ-2, -3, -5, -11, -13, and -14). The strain distribution pattern of DHEA-induced GC tumor susceptibility versus resistance was compared with strain distribution patterns for 35 different loci known to distinguish SWR and SJL progenitor strains. A complete match of DHEA-induced GC tumors with pancreas-2 (Pan-2) on mouse chromosome 4 was found. We have named this new locus GC tumor susceptibility (Gct), with the Gcts (susceptible) allele found in SWR and the Gctr (resistant) allele found in SJL mice. The Gct locus is closely linked to pancreas-2, Pan-2, but the order of genes is not yet confirmed. In addition, data from F1 progeny of matings between SWR and selected inbred strains provide suggestive evidence for a second gene controlling GC tumor incidence that we hypothesize involves steroid metabolism. Differences in GC tumor incidence data from reciprocal F1 progeny of matings between SWR and SJL mice reveal a strong maternal effect that may represent yet a third gene. These data support a heritable basis for GC tumorigenesis in the SWR model involving a small number of genes.

Links

J:9301 – Mouse Genome Informatics
2970296 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
SWR/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

2.5

SWXJ1/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

1.8

SWXJ4/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

1.2

SWXJ9/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

15

SWXJ6/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ7/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ8/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ10/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ12/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SJL/Bm Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ2/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ3/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ5/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ11/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ13/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWXJ14/BmJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SJL/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SWR/Bm x SJL/Bm)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

2.0

(SWR/Bm x ST/bJ)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

5.2

ST/bJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SWR/Bm x AKR/J)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SWR/Bm x MA/MyJ)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SWR/Bm x RIIIS/J)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SWR/Bm x RF/J)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

(SWR/Bm x BUB/BnJ)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

9.8

(SWR/Bm x PL/J)F1 Ovary - Granulosa cell tumor Ovary - Granulosa cell

16

AKR/J Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

MA/MyJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

RIIIS/J Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

RF/J Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

BUB/BnJ Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

PL/J Ovary - Granulosa cell tumor Ovary - Granulosa cell

0

SWR/Bm Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

19 - 24

SWXJ1/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

7.9 - 18

SWXJ4/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

1.1 - 8.2

SWXJ6/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0 - 11

SWXJ7/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0 - 14

SWXJ8/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

24 - 44

SWXJ10/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0 - 2.8

SWXJ12/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0.9 - 8.3

SJL/Bm Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

SWXJ2/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

SWXJ3/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

SWXJ5/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

SWXJ11/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

SWXJ13/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

SWXJ14/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0

(SJL/Bm x SWR/Bm)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

1.8

(SWR/Bm x SJL/Bm)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

14

(SWR/Bm x AKR/J)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

3.1

(SWR/Bm x MA/MyJ)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

3.4

(SWR/Bm x RIIIS/J)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

4.6

(SWR/Bm x RF/J)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0.9

(SWR/Bm x ST/bJ)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

22

(SWR/Bm x BUB/BnJ)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

14

(SWR/Bm x PL/J)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

10

SWXJ9/BmJ Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

37 - 41

(SWR/Bm x C57BL/6J)F1 Ovary - Granulosa cell tumor
  • dehydroepiandrosterone (DHEA)
Ovary - Granulosa cell

0