Reference SummaryMalkinson AM, J Natl Cancer Inst 1985 Nov;75(5):971-4

Title

Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model.

Authors

Malkinson AM; Nesbitt MN; Skamene E

Journal

J Natl Cancer Inst

Volume

75

Issue

5

Year

1985

Pages

971-4

Abstract

For insight into the number of genes governing differential susceptibility such as in mice of the inbred strain A/J (A) highly susceptible to the induction of pulmonary adenomas by urethan in comparison to resistant strain C57BL/6J (B6) mice, tumor induction was studied in the AXB and BXA series of recombinant inbred (RI) strains derived respectively from A female X B6 male and B6 female X A male ancestral lines. Mice from 46 of these lines were given injections with 1 mg urethan/g (body wt), and the tumor number was assessed 4 months later. Lung tumor multiplicity for several RI lines was independently characterized in the Boulder, CO, and Montreal laboratories, and very similar numbers were obtained. Most lines had multiplicities intermediate to those of the progenitor strains, clearly indicating that more than a single gene accounted for the differences in lung tumor susceptibility between A and B6. The tumor incidence and multiplicity data fit very closely to what would be expected under a three-locus model, and we designated these genes Pas for pulmonary adenoma susceptibility. One locus called Pas-1 had an effect on tumor multiplicity greater than that of the other loci.

Links

J:8075 – Mouse Genome Informatics
3863994 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
AXB1 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB2 Lung adenoma
  • urethane (ethyl carbamate)
Lung

36

AXB3 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB4 Lung adenoma
  • urethane (ethyl carbamate)
Lung

73

AXB5 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB6 Lung adenoma
  • urethane (ethyl carbamate)
Lung

86

AXB7 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB8 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB9 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB10 Lung adenoma
  • urethane (ethyl carbamate)
Lung

17

AXB11 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB12 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB13 Lung adenoma
  • urethane (ethyl carbamate)
Lung

43

AXB14 Lung adenoma
  • urethane (ethyl carbamate)
Lung

83

AXB15 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB17 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB18 Lung adenoma
  • urethane (ethyl carbamate)
Lung

80

AXB19 Lung adenoma
  • urethane (ethyl carbamate)
Lung

83

AXB20 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB21 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB22 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB23 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB24 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

AXB25 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA1 Lung adenoma
  • urethane (ethyl carbamate)
Lung

44

BXA2 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA3 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA4 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA6 Lung adenoma
  • urethane (ethyl carbamate)
Lung

50

BXA7 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA8 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA9 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA10 Lung adenoma
  • urethane (ethyl carbamate)
Lung

80

BXA11 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA12 Lung adenoma
  • urethane (ethyl carbamate)
Lung

67

BXA13 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA14 Lung adenoma
  • urethane (ethyl carbamate)
Lung

83

BXA16 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA17 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA18 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA19 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA20 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA22 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA23 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA24 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

BXA25 Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

A/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

100

C57BL/6J Lung adenoma
  • urethane (ethyl carbamate)
Lung

48

BALB/cByJ Lung tumor
  • urethane (ethyl carbamate)
Lung

observed