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Reference
Title: Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes.
Authors: Thaete LG; Nesbitt MN; Malkinson AM
Journal: Cancer Lett
Volume: 61
Issue: 1
Year: 1991
Pages: 15-20
Abstract: Urethane-induced, lung adenoma multiplicity and histologic type vary among mouse strains. We asked whether the Pas genes which control multiplicity also determine adenoma structure. Lung adenomas from inbred mice, F1 hybrids, and recombinant inbred mice were classified by growth pattern as either solid or papillary. Since no correlation was observed between adenoma multiplicity and histologic type, no linkage apparently exists between the Pas genes and adenoma morphology. We propose the name Pah (Pulmonary Adenoma Histologic type) for the genes controlling lung adenoma growth patterns. Genetic analysis indicated dominance of the papillary phenotype, and that two or more Pah genes determine adenoma structure.
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J:796  Mouse Genome Informatics
1764694  National Library of Medicine/PubMed