Reference SummaryThaete LG, Cancer Lett 1991 Dec 9;61(1):15-20

Title

Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes.

Authors

Thaete LG; Nesbitt MN; Malkinson AM

Journal

Cancer Lett

Volume

61

Issue

1

Year

1991

Pages

15-20

Abstract

Urethane-induced, lung adenoma multiplicity and histologic type vary among mouse strains. We asked whether the Pas genes which control multiplicity also determine adenoma structure. Lung adenomas from inbred mice, F1 hybrids, and recombinant inbred mice were classified by growth pattern as either solid or papillary. Since no correlation was observed between adenoma multiplicity and histologic type, no linkage apparently exists between the Pas genes and adenoma morphology. We propose the name Pah (Pulmonary Adenoma Histologic type) for the genes controlling lung adenoma growth patterns. Genetic analysis indicated dominance of the papillary phenotype, and that two or more Pah genes determine adenoma structure.

Links

J:796 – Mouse Genome Informatics
1764694 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
A/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

very high

C57BL/6J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB1 Lung adenoma
  • urethane (ethyl carbamate)
Lung

very high

AXB5 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB6 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB7 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB8 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB9 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB10 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB11 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB12 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB13 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB14 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB15 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB17 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB18 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB19 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB20 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB21 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB22 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB23 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB24 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

AXB25 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA2 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA4 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA6 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA8 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA9 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA10 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA11 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA12 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA13 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA14 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA18 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA19 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA20 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA22 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA23 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA24 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

BXA25 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

NGP/N Lung adenoma
  • urethane (ethyl carbamate)
Lung

very high

GRS/SN Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

MA/MyJ Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

ST/bN Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

PL/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

LP/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

CBA/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

C58/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

SM/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

SJL/J Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

(A/J x MA/MyJ)F1 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

(A/J x AKR/J)F1 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed

(A/J x DBA/2J)F1 Lung adenoma
  • urethane (ethyl carbamate)
Lung

observed