Reference SummaryLipman RD, J Gerontol A Biol Sci Med Sci 2002 Apr;57(4):B153-7

Title

Effect of calorie restriction on mortality kinetics in inbred strains of mice following 7,12-dimethylbenz[a]anthracene treatment.

Authors

Lipman RD

Journal

J Gerontol A Biol Sci Med Sci

Volume

57

Issue

4

Year

2002

Pages

B153-7

Abstract

Calorie restriction (CR) has long been known to increase longevity and to delay the onset and to decrease the incidence of many age-related disease processes. The mechanism(s) by which these outcomes are attained is unidentified. This experiment was designed to examine whether differences existed in the extent to which various inbred strains of mice respond to CR. This work explored whether carcinogen-treated animals could be used to facilitate this aim by decreasing the time needed to observe differences in mortality kinetics between CR mice and ad libitum (AL) fed controls. Female mice from each of eight strains (A/J, BALB/c, C3H, C57BL/6, DBA/2J, FVB/J, NMRI, and 129/J) were given a single oral dose (65 mg/kg) of the carcinogen 7,12-dimethylbenz[a]anthracene and subsequently fed AL or calorically restricted. Following carcinogen treatment, the spectrum of lesions observed demonstrated genotypic variability, thereby complicating comparison among the inbred strains examined. However, in terms of the magnitude of alteration in mortality kinetics observed, a statistical analysis revealed that differences exist among the various strains of mice in their response.

Links

J:75723 – Mouse Genome Informatics
11909880 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
129P3/J Blood vessel hemangiosarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

55

A/JOlaHsd Blood vessel hemangiosarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

3

BALB/cAnNHsd Blood vessel hemangiosarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

5

C3H/HeNHsd Blood vessel hemangiosarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

3

C57BL/6NHsd Blood vessel hemangiosarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

6

FVB/NJ Blood vessel hemangiosarcoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Blood vessel

9

129P3/J Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

13

A/JOlaHsd Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

23

BALB/cAnNHsd Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

10

C3H/HeNHsd Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

20

C57BL/6NHsd Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

35

DBA/2NHsd Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

24

FVB/NJ Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

16

NMRI Leukocyte lymphoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Leukocyte

19

129P3/J Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

13

A/JOlaHsd Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

100

BALB/cAnNHsd Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

23

C3H/HeNHsd Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

6

C57BL/6NHsd Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

3

DBA/2NHsd Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

6

FVB/NJ Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

78

NMRI Lung adenoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Lung

81

129P3/J Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

3

A/JOlaHsd Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

3

BALB/cAnNHsd Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

10

C3H/HeNHsd Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

37

DBA/2NHsd Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

9

FVB/NJ Mammary gland adenocarcinoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

3

129P3/J Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

26

A/JOlaHsd Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

39

BALB/cAnNHsd Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

20

C3H/HeNHsd Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

69

DBA/2NHsd Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

48

FVB/NJ Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

6

NMRI Mammary gland hyperplasia
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Mammary gland

3

A/JOlaHsd Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

32

BALB/cAnNHsd Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

20

C3H/HeNHsd Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

46

C57BL/6NHsd Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

26

DBA/2NHsd Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

33

FVB/NJ Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

44

NMRI Ovary - Granulosa cell tumor
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary - Granulosa cell

51

129P3/J Ovary cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

5

A/JOlaHsd Ovary cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

13

BALB/cAnNHsd Ovary cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

8

C57BL/6NHsd Ovary cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

24

DBA/2NHsd Ovary cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

12

NMRI Ovary cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Ovary

3

A/JOlaHsd Uterus cyst
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

6

BALB/cAnNHsd Uterus cyst
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

3

C3H/HeNHsd Uterus cyst
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

9

DBA/2NHsd Uterus cyst
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

12

129P3/J Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

24

A/JOlaHsd Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

3

BALB/cAnNHsd Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

15

C3H/HeNHsd Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

3

C57BL/6NHsd Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

32

DBA/2NHsd Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

9

FVB/NJ Uterus cyst - hemorrhagic
  • 7,12-dimethylbenz[a]anthracene (DMBA)
Uterus

3

A/JOlaHsd (Unspecified organ) adenoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
(Unspecified organ)

19

FVB/NJ (Unspecified organ) adenoacanthoma
  • 7,12-dimethylbenz[a]anthracene (DMBA)
(Unspecified organ)

3