Reference SummaryMoser AR, Cancer Res 2001 Apr 15;61(8):3480-5

Title

Genetic background affects susceptibility to mammary hyperplasias and carcinomas in Apc(min)/+ mice.

Authors

Moser AR; Hegge LF; Cardiff RD

Journal

Cancer Res

Volume

61

Issue

8

Year

2001

Pages

3480-5

Abstract

Treatment of female C57BL/6J (B6) mice carrying the mutant Min allele of the adenomatous polyposis coli (Apc) gene with ethylnitrosourea (ENU) results in approximately 90% of mice developing an average of three mammary tumors within 65 days. As a first step in the identification of loci modifying susceptibility to ENU-induced mammary tumors and hyperplasias, we have tested ENU-treated Apc(Min)/+ (Min/+) mice on several hybrid backgrounds for susceptibility to mammary and intestinal tumors. C57BR/cdJxB6 (BRB6) Min/+ mice were more sensitive to development of mammary squamous cell carcinomas than B6 Min/+ mice. In contrast, Min/+ hybrids between B6 and FVB/NTac (FVB), 129X1/SvJ (129X1), and 129S6/SvEvTac (129S6) were all significantly more resistant to mammary carcinoma development. However, mice from these three crosses developed more focal mammary hyperplasias than did the B6 or BRB6 Min/+ mice. Susceptibility to intestinal tumors was independent of mammary tumor susceptibility in most hybrids. These results indicate that genetic background can affect independently the phenotypes conferred by the Min allele of APC:

Links

J:68915 – Mouse Genome Informatics
11309311 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine tumor Intestine

100

C57BL/6J-ApcMin/+ Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

100

C57BL/6J Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

0

BRB6F1-ApcMin/+ Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

100

BRB6F1-ApcMin/+ Intestine tumor Intestine

100

(C57BR/cdJ x C57BL/6J)F1 Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

0

129S6B6F1-ApcMin/+ Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

100

129S6B6F1-ApcMin/+ Intestine tumor Intestine

100

(129S6/SvEvTac x C57BL/6J)F1 Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

0

129X1B6F1-ApcMin/+ Intestine tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Intestine

100

129X1B6F1-ApcMin/+ Intestine tumor Intestine

100

(129X1/SvJ x C57BL/6J)F1 Intestine tumor
  • 1-ethyl-1-nitrosourea (ENU)
Intestine

0

FVBB6F1-ApcMin/+ Intestine tumor
  • 1-ethyl-1-nitrosourea (ENU)
Intestine

100

FVBB6F1-ApcMin/+ Intestine tumor Intestine

100

(FVB/NTac x C57BL/6J)F1 Intestine tumor
  • 1-ethyl-1-nitrosourea (ENU)
Intestine

0

C57BL/6J-ApcMin/+ Mammary gland lesion
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

38

BRB6F1-ApcMin/+ Mammary gland lesion
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

39

129S6B6F1-ApcMin/+ Mammary gland lesion
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

65

129X1B6F1-ApcMin/+ Mammary gland lesion
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

73

(129X1/SvJ x C57BL/6J)F1 Mammary gland lesion
  • 1-ethyl-1-nitrosourea (ENU)
Mammary gland

observed

FVBB6F1-ApcMin/+ Mammary gland lesion
  • 1-ethyl-1-nitrosourea (ENU)
Mammary gland

100

C57BL/6J-ApcMin/+ Mammary gland tumor Mammary gland

0 - 5

C57BL/6J-ApcMin/+ Mammary gland tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

93

C57BL/6J Mammary gland tumor Mammary gland

0

BRB6F1-ApcMin/+ Mammary gland tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

94

BRB6F1-ApcMin/+ Mammary gland tumor Mammary gland

0

(C57BR/cdJ x C57BL/6J)F1 Mammary gland tumor Mammary gland

0

129S6B6F1-ApcMin/+ Mammary gland tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

41

129S6B6F1-ApcMin/+ Mammary gland tumor Mammary gland

0

(129S6/SvEvTac x C57BL/6J)F1 Mammary gland tumor Mammary gland

0

129X1B6F1-ApcMin/+ Mammary gland tumor
  • N-ethyl-N-nitrosourea (N-nitrosoethylurea) (ENU)
Mammary gland

9.1

129X1B6F1-ApcMin/+ Mammary gland tumor Mammary gland

0

(129X1/SvJ x C57BL/6J)F1 Mammary gland tumor Mammary gland

0

FVBB6F1-ApcMin/+ Mammary gland tumor
  • 1-ethyl-1-nitrosourea (ENU)
Mammary gland

17

FVBB6F1-ApcMin/+ Mammary gland tumor Mammary gland

0

(FVB/NTac x C57BL/6J)F1 Mammary gland tumor Mammary gland

0