Reference SummaryWang TC, Gastroenterology 2000 Jan;118(1):36-47

Title

Synergistic interaction between hypergastrinemia and helicobacter infection in a mouse model of gastric cancer

Authors

Wang TC; Dangler CA; Chen D; Goldenring JR; Koh T; Raychowdhury R; Coffey RJ; Ito S; Varro A; Dockray GJ; Fox JG

Journal

Gastroenterology

Volume

118

Issue

1

Year

2000

Pages

36-47

Abstract

Background & Aims: Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined. Methods: The effects of hypergastrinemia, and possible synergy with Helicobacter felis infection, were investigated in insulin-gastrin (INS-GAS) transgenic mice. Results: INS-GAS mice initially showed mild hypergastrinemia, increased maximal gastric acid secretion, and increased parietal cell number but later progressed to decreased parietal cell number and hypochlorhydria. Development of gastric atrophy was associated with increased expression of growth factors, heparin-binding epidermal growth factor and transforming growth factor alpha. At 20 months of age, INS-GAS mice showed no evidence of increased enterochromaffin-like cell number, but instead exhibited gastric metaplasia, dysplasia, carcinoma in situ, and gastric cancer with vascular invasion. Invasive gastric carcinoma was observed in 6 of 8 INS-GAS mice that were >20 months old. Helicobacter felis infection of INS-GAS mice led to accelerated (

Links

J:59575 – Mouse Genome Informatics
10611152 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/NTac Stomach - Glandular carcinoma Stomach - Glandular

0

FVB/NTac Stomach - Glandular carcinoma
  • Helicobacter felis
Stomach - Glandular

0

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular carcinoma Stomach - Glandular

0 - 13

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular carcinoma
  • Helicobacter felis
Stomach - Glandular

25 - 100

FVB/NTac Stomach - Glandular dysplasia Stomach - Glandular

0

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular dysplasia Stomach - Glandular

0 - 100

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular dysplasia
  • Helicobacter felis
Stomach - Glandular

observed - 100

FVB/NTac Stomach - Glandular hyperplasia - foveolar
  • Helicobacter felis
Stomach - Glandular

observed

FVB/NTac Stomach - Glandular hyperplasia - foveolar Stomach - Glandular

0

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular hyperplasia - foveolar Stomach - Glandular

observed - 100

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular hyperplasia - foveolar
  • Helicobacter felis
Stomach - Glandular

observed

FVB/NTac Stomach - Glandular metaplasia Stomach - Glandular

0

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular metaplasia Stomach - Glandular

100

FVB-Tg(Ins1-GAS)1Sbr Stomach - Glandular metaplasia
  • Helicobacter felis
Stomach - Glandular

observed