Reference SummaryCheo DL, Cancer Res 1999 Feb 15;59(4):771-5

Title

Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice.

Authors

Cheo DL; Burns DK; Meira LB; Houle JF; Friedberg EC

Journal

Cancer Res

Volume

59

Issue

4

Year

1999

Pages

771-5

Abstract

Mice that are genetically engineered to mimic the human hereditary cancer-prone DNA repair-defective disease xeroderma pigmentosum (XP) are highly predisposed to UV radiation-induced skin cancer. It is not clear, however, whether XP mice or humans are predisposed to cancers in other tissues associated with exposure to environmental carcinogens. To test the importance of nucleotide excision repair in protection against chemical carcinogenesis in internal organs, we treated XPC mutant (XPC-/-) mice with 2-acetylaminofluorene and NOH-2-acetylaminofluorene, We observed a significantly higher incidence of chemically induced Liver and lung tumors in XPC-/- mice compared with normal and heterozygous littermates. In addition, the progression of liver tumors in XPC-/- Trp53(+/-) mice is accelerated compared with XPC-/- Trp53(+/+) animals. Finally, we demonstrate a higher incidence of spontaneous testicular tumors in XPC-/- Trp53(-/-) double mutant mice compared with XPC+/+ Trp53(-/-) mice.

Links

J:52823 – Mouse Genome Informatics
10029060 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
B6;129-Trp53tm1Brd/+ Xpctm1Ecf Bone osteosarcoma Bone

observed

B6;129 Liver hepatocellular carcinoma
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129 Liver hepatocellular carcinoma
  • N-hydroxy-2-acetylaminofluorene
Liver

0

B6;129-Xpctm1Ecf/+ Liver hepatocellular carcinoma
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129-Xpctm1Ecf/+ Liver hepatocellular carcinoma
  • N-hydroxy-2-acetylaminofluorene
Liver

0

B6;129-Xpctm1Ecf Liver hepatocellular carcinoma
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129-Xpctm1Ecf Liver hepatocellular carcinoma
  • N-hydroxy-2-acetylaminofluorene
Liver

12.5

B6;129-Trp53tm1Brd/+ Liver hepatocellular carcinoma
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129-Trp53tm1Brd/+ Liver hepatocellular carcinoma
  • N-hydroxy-2-acetylaminofluorene
Liver

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Liver hepatocellular carcinoma
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Liver hepatocellular carcinoma
  • N-hydroxy-2-acetylaminofluorene
Liver

14

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Liver hepatocellular carcinoma
  • 2-acetylaminofluorene (AAF)
Liver

14

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Liver hepatocellular carcinoma
  • N-hydroxy-2-acetylaminofluorene
Liver

60

B6;129 Liver hyperplasia
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129 Liver hyperplasia
  • N-hydroxy-2-acetylaminofluorene
Liver

22

B6;129-Xpctm1Ecf/+ Liver hyperplasia
  • 2-acetylaminofluorene (AAF)
Liver

7.1

B6;129-Xpctm1Ecf/+ Liver hyperplasia
  • N-hydroxy-2-acetylaminofluorene
Liver

11

B6;129-Xpctm1Ecf Liver hyperplasia
  • 2-acetylaminofluorene (AAF)
Liver

29

B6;129-Xpctm1Ecf Liver hyperplasia
  • N-hydroxy-2-acetylaminofluorene
Liver

62.5

B6;129-Trp53tm1Brd/+ Liver hyperplasia
  • 2-acetylaminofluorene (AAF)
Liver

0

B6;129-Trp53tm1Brd/+ Liver hyperplasia
  • N-hydroxy-2-acetylaminofluorene
Liver

9.1

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Liver hyperplasia
  • 2-acetylaminofluorene (AAF)
Liver

18

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Liver hyperplasia
  • N-hydroxy-2-acetylaminofluorene
Liver

9.5

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Liver hyperplasia
  • 2-acetylaminofluorene (AAF)
Liver

14

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Liver hyperplasia
  • N-hydroxy-2-acetylaminofluorene
Liver

20

B6;129 Lung adenocarcinoma
  • 2-acetylaminofluorene (AAF)
Lung

33

B6;129 Lung adenocarcinoma
  • N-hydroxy-2-acetylaminofluorene
Lung

0

B6;129-Xpctm1Ecf/+ Lung adenocarcinoma
  • 2-acetylaminofluorene (AAF)
Lung

0

B6;129-Xpctm1Ecf/+ Lung adenocarcinoma
  • N-hydroxy-2-acetylaminofluorene
Lung

11

B6;129-Xpctm1Ecf Lung adenocarcinoma
  • 2-acetylaminofluorene (AAF)
Lung

29

B6;129-Xpctm1Ecf Lung adenocarcinoma
  • N-hydroxy-2-acetylaminofluorene
Lung

37.5

B6;129-Trp53tm1Brd/+ Lung adenocarcinoma
  • 2-acetylaminofluorene (AAF)
Lung

14

B6;129-Trp53tm1Brd/+ Lung adenocarcinoma
  • N-hydroxy-2-acetylaminofluorene
Lung

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Lung adenocarcinoma
  • 2-acetylaminofluorene (AAF)
Lung

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Lung adenocarcinoma
  • N-hydroxy-2-acetylaminofluorene
Lung

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Lung adenocarcinoma
  • 2-acetylaminofluorene (AAF)
Lung

43

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Lung adenocarcinoma
  • N-hydroxy-2-acetylaminofluorene
Lung

40

B6;129 Lung adenoma
  • 2-acetylaminofluorene (AAF)
Lung

0

B6;129 Lung adenoma
  • N-hydroxy-2-acetylaminofluorene
Lung

11

B6;129-Xpctm1Ecf/+ Lung adenoma
  • 2-acetylaminofluorene (AAF)
Lung

0

B6;129-Xpctm1Ecf/+ Lung adenoma
  • N-hydroxy-2-acetylaminofluorene
Lung

0

B6;129-Xpctm1Ecf Lung adenoma
  • 2-acetylaminofluorene (AAF)
Lung

14

B6;129-Xpctm1Ecf Lung adenoma
  • N-hydroxy-2-acetylaminofluorene
Lung

37.5

B6;129-Trp53tm1Brd/+ Lung adenoma
  • 2-acetylaminofluorene (AAF)
Lung

0

B6;129-Trp53tm1Brd/+ Lung adenoma
  • N-hydroxy-2-acetylaminofluorene
Lung

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Lung adenoma
  • 2-acetylaminofluorene (AAF)
Lung

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ Lung adenoma
  • N-hydroxy-2-acetylaminofluorene
Lung

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Lung adenoma
  • 2-acetylaminofluorene (AAF)
Lung

14

B6;129-Trp53tm1Brd/+ Xpctm1Ecf Lung adenoma
  • N-hydroxy-2-acetylaminofluorene
Lung

40

B6;129-Trp53tm1Brd Xpctm1Ecf Testis - Germ cell teratocarcinoma Testis - Germ cell

observed

B6;129-Trp53tm1Brd Xpctm1Ecf/+ Testis - Germ cell teratocarcinoma Testis - Germ cell

observed

B6;129-Trp53tm1Brd Testis - Germ cell teratocarcinoma Testis - Germ cell

observed

B6;129-Trp53tm1Brd Xpctm1Ecf Testis tumor Testis

54

B6;129-Trp53tm1Brd Xpctm1Ecf/+ Testis tumor Testis

36

B6;129-Trp53tm1Brd Testis tumor Testis

30

B6;129 (Unspecified organ) neoplasia (Unspecified organ)

0

B6;129-Xpctm1Ecf/+ (Unspecified organ) neoplasia (Unspecified organ)

0

B6;129-Xpctm1Ecf (Unspecified organ) neoplasia (Unspecified organ)

0

B6;129-Trp53tm1Brd/+ (Unspecified organ) neoplasia (Unspecified organ)

0

B6;129-Trp53tm1Brd/+ Xpctm1Ecf/+ (Unspecified organ) neoplasia (Unspecified organ)

0

B6;129-Trp53tm1Brd Xpctm1Ecf (Unspecified organ) tumor (Unspecified organ)

100

B6;129-Trp53tm1Brd Xpctm1Ecf/+ (Unspecified organ) tumor (Unspecified organ)

100

B6;129-Trp53tm1Brd (Unspecified organ) tumor (Unspecified organ)

100