Reference SummaryMaroulakou IG, Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11236-40

Title

Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene.

Authors

Maroulakou IG; Anver M; Garrett L; Green JE

Journal

Proc Natl Acad Sci U S A

Volume

91

Issue

23

Year

1994

Pages

11236-40

Abstract

A transgenic mouse model for prostate and mammary cancer has been developed in mice containing a recombinant gene expressing the simian virus 40 early-region transforming sequences under the regulatory control of the rat prostatic steroid binding protein [C3(1)] gene. Male transgenic mice develop prostatic hyperplasia in early life that progresses to adenoma or adenocarcinoma in most animals surviving to longer than 7 months of age. Prostate cancer metastases to lung have been observed. Female animals from the same founder lines generally develop mammary hyperplasia by 3 months of age with subsequent development of mammary adenocarcinoma by 6 months of age in 100% of the animals. The development of tumors correlates with the expression of the transgene as determined by Northern blot and immunohistochemical analyses. The results of these experiments demonstrate that the C3(1) regulatory region used in these experiments is useful for targeting expression to the prostate and mammary gland. To our knowledge, this experimental system is the first reported transgenic mouse model for prostate cancer. These transgenic animals offer the opportunity to study hormone response elements in vivo and the multistage progression from normal tissue to carcinoma in the prostate and mammary glands.

Links

J:52786 – Mouse Genome Informatics
7972041 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
FVB/N-Tg(C3-1-TAg)kJeg Bone osteosarcoma Bone

100

FVB/N-Tg(C3-1-TAg)iJeg Bone osteosarcoma Bone

100

FVB/N-Tg(C3-1-TAg)lJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100

FVB/N-Tg(C3-1-TAg)fJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100

FVB/N-Tg(C3-1-TAg)jJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100

FVB/N-Tg(C3-1-TAg)gJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100

FVB/N-Tg(C3-1-TAg)kJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100

FVB/N-Tg(C3-1-TAg)iJeg Connective tissue - Cartilage dysplasia Connective tissue - Cartilage

100

FVB/N-Tg(C3-1-TAg)lJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100

FVB/N-Tg(C3-1-TAg)fJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100

FVB/N-Tg(C3-1-TAg)jJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100

FVB/N-Tg(C3-1-TAg)gJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100

FVB/N-Tg(C3-1-TAg)iJeg Eye - Harderian gland hyperplasia Eye - Harderian gland

100

FVB/N-Tg(C3-1-TAg)lJeg Lung carcinoma Lung

100

FVB/N-Tg(C3-1-TAg)iJeg Lung carcinoma Lung

100

FVB/N-Tg(C3-1-TAg)cJeg Mammary gland adenocarcinoma Mammary gland

100

FVB/N-Tg(C3-1-TAg)lJeg Mammary gland adenocarcinoma Mammary gland

observed - 100

FVB/N-Tg(C3-1-TAg)fJeg Mammary gland adenocarcinoma Mammary gland

100

FVB/N-Tg(C3-1-TAg)#Jeg Mammary gland adenocarcinoma - type B Mammary gland

very high

FVB/N-Tg(C3-1-TAg)#Jeg Mammary gland hyperplasia Mammary gland

67

FVB/N-Tg(C3-1-TAg)lJeg Mammary gland hyperplasia Mammary gland

observed

FVB/N Mammary gland tumor Mammary gland

0

FVB/N-Tg(C3-1-TAg)lJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100

FVB/N-Tg(C3-1-TAg)fJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100

FVB/N-Tg(C3-1-TAg)jJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100

FVB/N-Tg(C3-1-TAg)gJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100

FVB/N-Tg(C3-1-TAg)kJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100

FVB/N-Tg(C3-1-TAg)iJeg Nose - Nasal cavity lesion Nose - Nasal cavity

100

FVB/N-Tg(C3-1-TAg)lJeg Nose - Nasal cavity tumor Nose - Nasal cavity

high

FVB/N-Tg(C3-1-TAg)#Jeg Prostate gland adenocarcinoma Prostate gland

high

FVB/N-Tg(C3-1-TAg)lJeg Prostate gland adenocarcinoma Prostate gland

observed

FVB/N-Tg(C3-1-TAg)cJeg Prostate gland adenocarcinoma Prostate gland

observed

FVB/N-Tg(C3-1-TAg)#Jeg Prostate gland adenoma Prostate gland

33

FVB/N-Tg(C3-1-TAg)kJeg Prostate gland hyperplasia Prostate gland

100

FVB/N-Tg(C3-1-TAg)iJeg Prostate gland hyperplasia Prostate gland

100

FVB/N-Tg(C3-1-TAg)#Jeg Prostate gland hyperplasia Prostate gland

observed

FVB/N-Tg(C3-1-TAg)lJeg Prostate gland hyperplasia Prostate gland

observed

FVB/N-Tg(C3-1-TAg)cJeg Prostate gland hyperplasia Prostate gland

observed

FVB/N Prostate gland tumor Prostate gland

0

FVB/N-Tg(C3-1-TAg)lJeg Salivary gland lesion Salivary gland

100

FVB/N-Tg(C3-1-TAg)fJeg Salivary gland lesion Salivary gland

100

FVB/N-Tg(C3-1-TAg)jJeg Salivary gland lesion Salivary gland

100

FVB/N-Tg(C3-1-TAg)gJeg Salivary gland lesion Salivary gland

100

FVB/N-Tg(C3-1-TAg)kJeg Salivary gland lesion Salivary gland

100

FVB/N-Tg(C3-1-TAg)iJeg Salivary gland lesion Salivary gland

100

FVB/N-Tg(C3-1-TAg)gJeg Thyroid gland adenoma Thyroid gland

100

FVB/N-Tg(C3-1-TAg)fJeg Thyroid gland carcinoma Thyroid gland

100

FVB/N-Tg(C3-1-TAg)jJeg Thyroid gland hyperplasia Thyroid gland

100

FVB/N-Tg(C3-1-TAg)iJeg Thyroid gland hyperplasia Thyroid gland

100