Reference Summaryvan der Houven van Oordt CW, Genes Chromosomes Cancer 1999 Mar;24(3):191-8

Title

The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model.

Authors

van der Houven van Oordt CW; Smits R; Schouten TG; Houwing-Duistermaat JJ; Williamson SL; Luz A; Meera Khan P; van der Eb AJ; Breuer ML; Fodde R

Journal

Genes Chromosomes Cancer

Volume

24

Issue

3

Year

1999

Pages

191-8

Abstract

The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the ApcMin model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.

Links

J:52560 – Mouse Genome Informatics
10451698 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
B6.129P2-Apctm1Rak/+ Connective tissue - Fibroblast desmoid Connective tissue - Fibroblast

very high

B6.129P2-Apctm1Rak/+ Connective tissue - Fibroblast desmoid
  • X-radiation
Connective tissue - Fibroblast

very high

AB6F1-Apctm1Rak/+ Connective tissue - Fibroblast desmoid Connective tissue - Fibroblast

very high

AB6F1-Apctm1Rak/+ Connective tissue - Fibroblast desmoid
  • X-radiation
Connective tissue - Fibroblast

very high

CB6F1-Apctm1Rak/+ Connective tissue - Fibroblast desmoid Connective tissue - Fibroblast

very high

CB6F1-Apctm1Rak/+ Connective tissue - Fibroblast desmoid
  • X-radiation
Connective tissue - Fibroblast

observed - very high

C3B6F1-Apctm1Rak/+ Connective tissue - Fibroblast desmoid Connective tissue - Fibroblast

very high

C3B6F1-Apctm1Rak/+ Connective tissue - Fibroblast desmoid
  • X-radiation
Connective tissue - Fibroblast

very high

B6.129P2-Apctm1Rak/+ Intestine tumor Intestine

very high

B6.129P2-Apctm1Rak/+ Intestine tumor
  • X-radiation
Intestine

very high

AB6F1-Apctm1Rak/+ Intestine tumor Intestine

high

AB6F1-Apctm1Rak/+ Intestine tumor
  • X-radiation
Intestine

very high

CB6F1-Apctm1Rak/+ Intestine tumor Intestine

very high

CB6F1-Apctm1Rak/+ Intestine tumor
  • X-radiation
Intestine

very high

C3B6F1-Apctm1Rak/+ Intestine tumor Intestine

very high

C3B6F1-Apctm1Rak/+ Intestine tumor
  • X-radiation
Intestine

very high

B6.129P2-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous Mammary gland

0

B6.129P2-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous
  • X-radiation
Mammary gland

50

AB6F1-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous Mammary gland

0

AB6F1-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous
  • X-radiation
Mammary gland

39

CB6F1-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous Mammary gland

6.7

CB6F1-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous
  • X-radiation
Mammary gland

25

C3B6F1-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous Mammary gland

6.7

C3B6F1-Apctm1Rak/+ Mammary gland carcinoma - adenosquamous
  • X-radiation
Mammary gland

0

B6.129P2-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor Ovary - Sex cord stromal cell

0

B6.129P2-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor
  • X-radiation
Ovary - Sex cord stromal cell

0

AB6F1-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor Ovary - Sex cord stromal cell

0

AB6F1-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor
  • X-radiation
Ovary - Sex cord stromal cell

0

CB6F1-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor Ovary - Sex cord stromal cell

0

CB6F1-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor
  • X-radiation
Ovary - Sex cord stromal cell

71

C3B6F1-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor Ovary - Sex cord stromal cell

0

C3B6F1-Apctm1Rak/+ Ovary - Sex cord stromal cell tumor
  • X-radiation
Ovary - Sex cord stromal cell

0

CB6F1 Ovary - Sex cord stromal cell tumor
  • X-radiation
Ovary - Sex cord stromal cell

0

B6.129P2-Apctm1Rak/+ Skin cyst Skin

high - very high

B6.129P2-Apctm1Rak/+ Skin cyst
  • X-radiation
Skin

very high

AB6F1-Apctm1Rak/+ Skin cyst Skin

very high

AB6F1-Apctm1Rak/+ Skin cyst
  • X-radiation
Skin

very high

CB6F1-Apctm1Rak/+ Skin cyst Skin

very high

CB6F1-Apctm1Rak/+ Skin cyst
  • X-radiation
Skin

very high

C3B6F1-Apctm1Rak/+ Skin cyst Skin

very high

C3B6F1-Apctm1Rak/+ Skin cyst
  • X-radiation
Skin

very high