Reference SummarySaez E, Nat Med 1998 Sep;4(9):1058-61

Title

Activators of the nuclear receptor PPARgamma enhance colon polyp formation.

Authors

Saez E; Tontonoz P; Nelson MC; Alvarez JG; Ming UT; Baird SM; Thomazy VA; Evans RM

Journal

Nat Med

Volume

4

Issue

9

Year

1998

Pages

1058-61

Abstract

A high-fat diet increases the risk of colon, breast and prostate cancer. The molecular mechanism by which dietary lipids promote tumorigenesis is unknown. Their effects may be mediated at least in part by the peroxisome proliferator-activated receptors (PPARs). These ligand-activated nuclear receptors modulate gene expression in response to fatty acids, lipid-derived metabolites and antidiabetic drugs. To explore the role of the PPARs in diet-induced carcinogenesis, we treated mice predisposed to intestinal neoplasia with a synthetic PPARgamma ligand. Reflecting the pattern of expression of PPARgamma in the gastrointestinal tract, treated mice developed a considerably greater number of polyps in the colon but not in the small intestine, indicating that PPARgamma activation may provide a molecular link between a high-fat diet and increased risk of colorectal cancer.

Links

J:49813 – Mouse Genome Informatics
9734400 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon carcinoma
  • troglitazone
Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon carcinoma Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon tumor
  • troglitazone
Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon tumor Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon tumor
  • sulindac
Intestine - Large Intestine - Colon

observed

C57BL/6J Intestine - Large Intestine - Colon tumor
  • troglitazone
Intestine - Large Intestine - Colon

0

C57BL/6J-ApcMin/+ Intestine - Small Intestine polyp
  • troglitazone
Intestine - Small Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine polyp Intestine - Small Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine tumor
  • sulindac
Intestine - Small Intestine

observed