Reference SummaryTremblay PJ, Mol Cell Biol 1989 Feb;9(2):854-9

Title

Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues.

Authors

Tremblay PJ; Pothier F; Hoang T; Tremblay G; Brownstein S; Liszauer A; Jolicoeur P

Journal

Mol Cell Biol

Volume

9

Issue

2

Year

1989

Pages

854-9

Abstract

Transgenic mice carrying the v-Ha-ras oncogene under the control of the mouse mammary tumor virus long terminal repeat were produced. These mice exhibit several phenotypes: mammary tumors, bilateral hyperplasia of the harderian lacrimal gland, primary bronchio-alveolar lung adenocarcinoma, and splenomegaly. High levels of the transgene RNA were detected in mammary, harderian, and lung tumors. Accumulation of cells of the myeloid lineages was found in enlarged spleens. This phenotype may represent an indirect effect of v-Ha-ras expression on myeloid progenitors. Our data illustrate the cell-specific effects of v-Ha-ras.

Links

J:46456 – Mouse Genome Informatics
2540427 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
STOCK Tg(MMTV-vHaras)2Pjo Eye - Harderian gland hyperplasia Eye - Harderian gland

92

STOCK Tg(MMTV-vHaras)3Pjo Eye - Harderian gland hyperplasia Eye - Harderian gland

0

STOCK Tg(MMTV-vHaras)4aPjo Eye - Harderian gland hyperplasia Eye - Harderian gland

0

STOCK Tg(MMTV-vHaras)4bPjo Eye - Harderian gland hyperplasia Eye - Harderian gland

87

STOCK Tg(MMTV-vHaras)5Pjo Eye - Harderian gland hyperplasia Eye - Harderian gland

26

STOCK Tg(MMTV-vHaras)#Pjo Eye - Harderian gland hyperplasia Eye - Harderian gland

observed

STOCK Tg(MMTV-vHaras)2Pjo Lung adenocarcinoma Lung

5.6

STOCK Tg(MMTV-vHaras)3Pjo Lung adenocarcinoma Lung

6.7

STOCK Tg(MMTV-vHaras)4aPjo Lung adenocarcinoma Lung

0

STOCK Tg(MMTV-vHaras)4bPjo Lung adenocarcinoma Lung

0

STOCK Tg(MMTV-vHaras)5Pjo Lung adenocarcinoma Lung

58

STOCK Tg(MMTV-vHaras)#Pjo Lung adenocarcinoma Lung

observed

STOCK Tg(MMTV-vHaras)#Pjo Mammary gland adenoacanthoma Mammary gland

observed

STOCK Tg(MMTV-vHaras)2Pjo Mammary gland adenocarcinoma Mammary gland

89

STOCK Tg(MMTV-vHaras)3Pjo Mammary gland adenocarcinoma Mammary gland

52

STOCK Tg(MMTV-vHaras)4aPjo Mammary gland adenocarcinoma Mammary gland

0

STOCK Tg(MMTV-vHaras)4bPjo Mammary gland adenocarcinoma Mammary gland

83

STOCK Tg(MMTV-vHaras)5Pjo Mammary gland adenocarcinoma Mammary gland

17

STOCK Tg(MMTV-vHaras)#Pjo Mammary gland adenocarcinoma Mammary gland

observed

STOCK Tg(MMTV-vHaras)3Pjo Mammary gland tumor Mammary gland

1.9

STOCK Tg(MMTV-vHaras)2Pjo Mammary gland tumor Mammary gland

0

STOCK Tg(MMTV-vHaras)4aPjo Mammary gland tumor Mammary gland

0

STOCK Tg(MMTV-vHaras)4bPjo Mammary gland tumor Mammary gland

0

STOCK Tg(MMTV-vHaras)5Pjo Mammary gland tumor Mammary gland

0

STOCK Tg(MMTV-vHaras)2Pjo Salivary gland adenocarcinoma Salivary gland

5.1

STOCK Tg(MMTV-vHaras)3Pjo Salivary gland adenocarcinoma Salivary gland

5.0

STOCK Tg(MMTV-vHaras)4aPjo Salivary gland adenocarcinoma Salivary gland

0

STOCK Tg(MMTV-vHaras)4bPjo Salivary gland adenocarcinoma Salivary gland

6.7

STOCK Tg(MMTV-vHaras)5Pjo Salivary gland adenocarcinoma Salivary gland

2.7

STOCK Tg(MMTV-vHaras)2Pjo Spleen - Red pulp hyperplasia Spleen - Red pulp

100

STOCK Tg(MMTV-vHaras)3Pjo Spleen - Red pulp hyperplasia Spleen - Red pulp

73

STOCK Tg(MMTV-vHaras)4aPjo Spleen - Red pulp hyperplasia Spleen - Red pulp

0

STOCK Tg(MMTV-vHaras)4bPjo Spleen - Red pulp hyperplasia Spleen - Red pulp

62.5

STOCK Tg(MMTV-vHaras)5Pjo Spleen - Red pulp hyperplasia Spleen - Red pulp

75

STOCK Tg(MMTV-vHaras)#Pjo Spleen - Red pulp hyperplasia Spleen - Red pulp

observed