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Reference
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Title: |
Subcapsular cell hyperplasia and mast cell infiltration in the adrenal cortex of mice: comparative study in 7 inbred strains. |
Authors: |
Kim JS; Kubota H; Kiuchi Y; Doi K; Saegusa J |
Journal: |
Exp Anim |
Volume: |
46 |
Issue: |
4 |
Year: |
1997 |
Pages: |
303-6 |
Abstract: |
Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13-15 months old) was frequent in both sexes of BALB/c, C3H/He, DBA/2J and IQI/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, C57BL/6, DBA/2J and IQI/Jic mice, but not in the C3H/He strain. Compared with other strains, IQI/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IQI/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion. |
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Additional Information in MTB |
Tumor Records (14) |
Strains (7) |
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Other Accession IDs |
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