Reference SummaryWasan HS, Proc Natl Acad Sci U S A 1997 Apr 1;94(7):3308-13

Title

Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice.

Authors

Wasan HS; Novelli M; Bee J; Bodmer WF

Journal

Proc Natl Acad Sci U S A

Volume

94

Issue

7

Year

1997

Pages

3308-13

Abstract

Significant differences in colon cancer incidence worldwide have led to the hypothesis that this variation can be explained largely by environmental, notably dietary influences. Although a positive correlation between dietary fat intake and incidence is suggested from some human epidemiological and rodent carcinogenesis studies, a direct association remains contentious. Using a spontaneous mouse tumor model of multiple intestinal neoplasia, we demonstrate that there is a generalized increase in tumor counts, in both the large and small bowel with higher dietary fat [standard (3%) fat versus high (15%) fat diet (mean +/- SD) 1.59 +/- 1.46 vs. 3.85 +/- 2.37 P < 0.001 and 21.36 +/- 7.4 vs. 31.3 +/- 9.7, respectively, P < 0.001]. Increasing dietary fat also increases polyp size in the small bowel. These changes appear independent of total calorific intake as assessed by body weights. Halving the crude fiber intake together with an increase in dietary fat from 3% to 10% did not have as marked an effect on tumor counts as an increase of fat alone to 15%, which also decreased survival (P < 0.05). These results demonstrate that increasing dietary fat intake from weaning can have a significant adverse effect on polyp numbers in mice genetically predisposed to intestinal tumor development. A further understanding of the biology of this interaction may provide novel strategies aimed at both colonic polyp prevention and treatment.

Links

J:39278 – Mouse Genome Informatics
9096389 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine - Large Intestine polyp Intestine - Large Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Large Intestine polyp
  • increased fat, decreased fiber
Intestine - Large Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Large Intestine polyp
  • high fat
Intestine - Large Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine polyp Intestine - Small Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine polyp
  • increased fat, decreased fiber
Intestine - Small Intestine

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine polyp
  • high fat
Intestine - Small Intestine

observed

C57BL/6J Intestine tumor Intestine

0

C57BL/6J-ApcMin/+ Mammary gland tumor Mammary gland

41

C57BL/6J-ApcMin/+ Mammary gland tumor
  • increased fat, decreased fiber
Mammary gland

20

C57BL/6J-ApcMin/+ Mammary gland tumor
  • high fat
Mammary gland

26