Reference SummaryDove WF, Cancer Res 1997 Mar 1;57(5):812-4

Title

Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.

Authors

Dove WF; Clipson L; Gould KA; Luongo C; Marshall DJ; Moser AR; Newton MA; Jacoby RF

Journal

Cancer Res

Volume

57

Issue

5

Year

1997

Pages

812-4

Abstract

We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6- Apc(Min)/+ mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9; P < 0.003), but there were no significant differences in the rest of the intestinal tract. We conclude that microbial status does not strongly alter the adenoma phenotype in this mouse model of familial adenomatous polyposis. In parallel, we have found that C57BL/6-Apc(Min)/+ mice mutated at the beige locus. Which controls natural killer activity, are also unaltered in adenoma multiplicity.

Links

J:38777 – Mouse Genome Informatics
9041176 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Lystbg-J Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Lystbg-J/+ Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

observed

C57BL/6J-ApcMin/+ Lystbg-J Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

observed

C57BL/6J-ApcMin/+ Lystbg-J/+ Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum

observed

C57BL/6J-ApcMin/+ Lystbg-J Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum

observed

C57BL/6J-ApcMin/+ Lystbg-J/+ Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

observed

C57BL/6J-ApcMin/+ Lystbg-J Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

observed

C57BL/6J-ApcMin/+ Lystbg-J/+ Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

observed