Reference SummaryBooth CJ, Lab Anim Sci 1995 Oct;45(5):497-502

Title

Hemangiomas and hemangiosarcomas in inbred laboratory mice.

Authors

Booth CJ; Sundberg JP

Journal

Lab Anim Sci

Volume

45

Issue

5

Year

1995

Pages

497-502

Abstract

Hemangiomas and hemangiosarcomas are rare, naturally developing tumors of blood vessels. In a retrospective study covering a period of 57 contiguous months between 1986 and 1991, four cavernous hemangiomas, eight capillary hemangiomas, and three hemangiosarcomas developed spontaneously in A/J, BALB/cJ, BALB/cByJ, C57BL/6J, NU/J, and 129/SvJ inbred mouse strains. When data were correlated to actual numbers of each sex in the colony, no sexual dimorphism was determined. At the time of submission, mice ranged in age from 100 to 434 days, with a mean of 217 days. Tumors principally affected the skin but were also diagnosed in the seminal vesicles, liver, muscle tissue, and cerebellum. Immunohistochemistry, with antisera directed against human von Willebrand factor (factor VIII-related antigen) as an endothelial cell marker, labeled mouse endothelial cells inconsistently. A monoclonal antibody directed against the smooth muscle actin isoform, but not the sarcomeric muscle actin isoform, outlined vascular structures in tumors and normal vascular smooth muscle in adjacent normal tissues.

Links

J:30363 – Mouse Genome Informatics
8569146 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/cJ Blood vessel hemangioma - capillary Blood vessel

observed

C57BL/6J Blood vessel hemangioma - capillary Blood vessel

observed

C57BL/6J Blood vessel hemangioma - capillary Liver

observed

A/J Blood vessel hemangioma - cavernous Blood vessel

observed

BALB/cByJ Blood vessel hemangioma - cavernous Seminal vesicle

observed

NU/J Blood vessel hemangioma - cavernous Blood vessel

observed

BALB/cJ Blood vessel hemangiosarcoma CNS - Brain - Cerebellum

observed

BALB/cJ Blood vessel hemangiosarcoma Blood vessel

observed

129X1/SvJ Blood vessel hemangiosarcoma Blood vessel

observed