Reference SummaryFrith CH, J Gerontol 1981 Sep;36(5):534-45

Title

Morphologic classification and correlation of incidence of hyperplastic and neoplastic hematopoietic lesions in mice with age.

Authors

Frith CH; Wiley LD

Journal

J Gerontol

Volume

36

Issue

5

Year

1981

Pages

534-45

Abstract

Information from the NCTR control pathology data base was examined to morphologically classify and correlate the incidence off hyperplastic and neoplastic hematopoietic lesions with age in over 15,000 male and female mice of a variety of strains. Hyperplasia affected lymphoid and reticular cells, erythropoietic and granulopoietic cells, mast cells, plasma cells and megakaryocytes. Neoplastic lesions included lymphocytic lymphoma, mixed cell lymphoma, histiocytic lymphoma, granulocytic leukemia, plasma cell neoplasms and mast cell neoplasms. Most hyperplastic and neoplastic hematopoietic lesions increased wtih age and most were slightly more common in the female than in the male mice.

Links

J:27153 – Mouse Genome Informatics
7264236 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
BALB/cStCrlfC3Hf/Nctr Erythrocyte hyperplasia Spleen

0.37 - 8.3

C57BL/6JfC3Hf/Nctr Erythrocyte hyperplasia Spleen

0.32 - 6.9

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Erythrocyte hyperplasia Spleen

0 - 15.1

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Erythrocyte hyperplasia Spleen

0 - 18.7

C3H Erythrocyte hyperplasia Spleen

1.4 - 15.4

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0

C3H Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell neoplasm Leukocyte - Lymphocyte - B-lymphocyte - Plasma cell

0

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte hyperplasia Lymph node

0 - 2.8

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte hyperplasia Spleen

0.10 - 10.5

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte hyperplasia Lymph node

0 - 4.0

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte hyperplasia Spleen

0 - 5.6

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Lymphocyte hyperplasia Lymph node

0 - 1.6

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Lymphocyte hyperplasia Spleen

0 - 5.9

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Lymphocyte hyperplasia Lymph node

0 - 3.4

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Lymphocyte hyperplasia Spleen

0 - 7.1

C3H Leukocyte - Lymphocyte hyperplasia Lymph node

0.24 - 0.98

C3H Leukocyte - Lymphocyte hyperplasia Spleen

0 - 19.9

BALB/cStCrlfC3Hf/Nctr Leukocyte - Lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte

0.28 - 7.5

C57BL/6JfC3Hf/Nctr Leukocyte - Lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte

0 - 2.9

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte

0 - 6.8

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte

0 - 7.8

C3H Leukocyte - Lymphocyte lymphoma - lymphoblastic Leukocyte - Lymphocyte

0 - 1.8

C57BL/6JfC3Hf/Nctr Leukocyte - Megakaryocyte hyperplasia Leukocyte - Megakaryocyte

0.66

BALB/cStCrlfC3Hf/Nctr Leukocyte - Monocyte - Macrophage - Histiocyte lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 0.63

C57BL/6JfC3Hf/Nctr Leukocyte - Monocyte - Macrophage - Histiocyte lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 4.0

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Monocyte - Macrophage - Histiocyte lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 6.8

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Monocyte - Macrophage - Histiocyte lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 6.7

C3H Leukocyte - Monocyte - Macrophage - Histiocyte lymphoma - histiocytic Leukocyte - Monocyte - Macrophage - Histiocyte

0 - 0.91

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell hyperplasia Lymph node

0.52

C57BL/6JfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell sarcoma - mast cell Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast cell

observed

BALB/cStCrlfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 8.0

C57BL/6JfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 5.6

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 4.2

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 8.3

C3H Leukocyte - Myelocyte (Granulocyte) hyperplasia Spleen

0 - 2.7

BALB/cStCrlfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0 - 0.25

C57BL/6JfC3Hf/Nctr Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0 - 1.6

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0

C3H Leukocyte - Myelocyte (Granulocyte) leukemia - myelocytic Leukocyte - Myelocyte (Granulocyte)

0 - 0.30

BALB/cStCrlfC3Hf/Nctr Leukocyte lymphoma - mixed Leukocyte

0 - 35.0

C57BL/6JfC3Hf/Nctr Leukocyte lymphoma - mixed Leukocyte

0 - 19.7

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Leukocyte lymphoma - mixed Leukocyte

0 - 28.6

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Leukocyte lymphoma - mixed Leukocyte

0 - 29.0

C3H Leukocyte lymphoma - mixed Leukocyte

0 - 7.3

BALB/cStCrlfC3Hf/Nctr Reticular cell hyperplasia Lymph node

0 - 1.4

BALB/cStCrlfC3Hf/Nctr Reticular cell hyperplasia Spleen

0.09 - 5.1

C57BL/6JfC3Hf/Nctr Reticular cell hyperplasia Lymph node

0 - 3.5

C57BL/6JfC3Hf/Nctr Reticular cell hyperplasia Spleen

0 - 5.1

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Reticular cell hyperplasia Lymph node

0 - 2.2

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F1 Reticular cell hyperplasia Spleen

0 - 4.2

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Reticular cell hyperplasia Lymph node

0 - 1.6

(C57BL/6JfC3Hf/Nctr x BALB/cStCrlfC3Hf/Nctr)F2 Reticular cell hyperplasia Spleen

0 - 2.1

C3H Reticular cell hyperplasia Lymph node

0 - 0.60

C3H Reticular cell hyperplasia Spleen

0.24 - 3.6