Reference SummaryHighman B, J Environ Pathol Toxicol 1978 Sep-Oct;1(1):1-30

Title

Pathological changes in female C3H mice continuously fed diets containing diethylstilbestrol or 17beta--estradiol.

Authors

Highman B; Norvell MJ; Shellenberger TE

Journal

J Environ Pathol Toxicol

Volume

1

Issue

1

Year

1978

Pages

1-30

Abstract

To study the long term effects of estrogen administration in mice, virgin female C3H/HeJ mice are being fed diets containing 0, 10, 100 or 500 ppb of diethylstilbestrol (DES) or 0, 100, 1000, or 5000 pph of 17beta-estradiol (E2) from 6 to 110 weeks of age. C3HeB/FeJ mice are being fed diets containing 08 10, 100, or 500 ppb DES FROM 6 TO 136 WEEKS OF AGE. Pathologic studies were conducted on 396 such mice sacrificed at 52 weeks and on over 500 others sacrificed at various intervals. After 52 weeks on 500 ppb DES or 5000 ppb E2, the cervix of both populations often showed stromal mucoid changes and adenosis characterized by focal replacement of squamous by columnar epithelium lining the cervical canal assoicated with glandular downgrowths into the subjacent stroma. The uterine horns showed hyperplastic glands, which often penetrated the muscularis, and focal endometrial and perivascular hyalin deposits. The ovaries showed atrophy with absence of corpora lutea. Ceroid deposits were increased in the ovaries and adrenals. Sternal bony trabeculae were increased. The incidence of uterine cervical adenosis and of mammary hyperplastic alveolar nodules and tumors (mainly type B, Dunn's classification), was higher in C3H/HeJ than in C3HeB/FeJ mice. Mice on lower doses of DES or E2 had less frequent and severe similar changes. Tumors observed to date only in estrogen-treated mice included 4 endometrial adenocarcinomas and an adenoacanthoma of a uterine horn, 14 cervical adenocarcinomas often appearing to arise from areas of adenosis, a vaginal squamous cell carcinoma, a cervical granular cell myoblastoma, 1 sternal and 3 cranial osteosarcomas, and a mesothelioma. The majority of the malignancies occurred in C3H/HeJ mice. These findings indicate that the mammary tumor virus factor facilitates DES-induced mammary tumorigenesis in C3H mice and may contribute to other DES-induced malignant and premalignant lesions.

Links

J:237478 – Mouse Genome Informatics
722180 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C3HeB/FeJ Bone - Skull osteosarcoma
  • diethylstilbestrol (DES)
  • corn oil
Bone - Skull

observed

C3H/HeJ Bone - Skull osteosarcoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Bone - Skull

observed

C3H/HeJ Bone - Skull osteosarcoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Bone - Skull

observed

C3H/HeJ Bone - Skull osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone - Skull

3.12

C3H/HeJ Bone - Skull osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone - Skull

2.08

C3H/HeJ Bone - Skull osteosarcoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Bone - Skull

observed - 2.86

C3HeB/FeJ Bone - Skull osteosarcoma
  • diethylstilbestrol (DES)
  • corn oil
Bone - Skull

2.7

C3H/HeJ Bone - Skull osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone - Skull

observed

C3H/HeJ Bone - Sternum hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone - Sternum

observed

C3H/HeJ Bone - Sternum osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone - Sternum

observed

C3H/HeJ Bone - Sternum osteosarcoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Lung

observed

C3H/HeJ Bone hyperplasia
  • MMTV - mouse mammary tumor virus
  • corn oil
Bone

0

C3H/HeJ Bone hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone

3.12

C3H/HeJ Bone hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone

2.63

C3H/HeJ Bone hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Bone

82

C3H/HeJ Bone hyperplasia
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Bone

0

C3H/HeJ Bone hyperplasia
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Bone

16

C3H/HeJ Bone hyperplasia
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Bone

82

C3HeB/FeJ Bone hyperplasia
  • corn oil
Bone

0

C3HeB/FeJ Bone hyperplasia
  • diethylstilbestrol (DES)
  • corn oil
Bone

5.56 - 7.69

C3HeB/FeJ Bone hyperplasia
  • diethylstilbestrol (DES)
  • corn oil
Bone

97.3

C3H/HeJ Intestine - Large Intestine - Rectum tumor
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Intestine - Large Intestine - Rectum

observed

C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • corn oil
Mammary gland

4.26

C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0 - 7.89

C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

7

C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Mammary gland

0

C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Mammary gland

5.56 - 8.33

C3HeB/FeJ Mammary gland adenocarcinoma
  • corn oil
Mammary gland

0

C3HeB/FeJ Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0

C3HeB/FeJ Mammary gland adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0

C3H/HeJ Mammary gland adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

observed

C3H/HeJ Mammary gland adenocarcinoma - type A
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

observed

C3H/HeJ Mammary gland adenocarcinoma - type B
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

observed

C3H/HeJ Mammary gland adenocarcinoma - type B
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

observed

C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • corn oil
Mammary gland

0

C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

3.12 - 14

C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

5.26

C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Mammary gland

0

C3H/HeJ Mammary gland hyperplasia - alveolar
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Mammary gland

2.78

C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Mammary gland

9

C3HeB/FeJ Mammary gland hyperplasia - alveolar
  • corn oil
Mammary gland

0

C3HeB/FeJ Mammary gland hyperplasia - alveolar
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0

C3HeB/FeJ Mammary gland hyperplasia - alveolar
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0

C3H/HeJ Mammary gland hyperplasia - alveolar
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

observed

C3H/HeJ Mammary gland tumor
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

observed

C3HeB/FeJ Mammary gland tumor
  • corn oil
Mammary gland

0

C3HeB/FeJ Mammary gland tumor
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0

C3HeB/FeJ Mammary gland tumor
  • diethylstilbestrol (DES)
  • corn oil
Mammary gland

0

C3H/HeJ Mesothelium mesothelioma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Mesothelium mesothelioma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Lymph node

observed

C3H/HeJ Muscle - Striated - Skeletal neoplasm - cystic
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Muscle - Striated - Skeletal

observed

C3HeB/FeJ Ovary - Germ cell teratoma
  • diethylstilbestrol (DES)
  • corn oil
Ovary - Germ cell

observed

C3H/HeJ Ovary - Granulosa cell tumor - granulosa cell
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Ovary - Granulosa cell

observed

C3H/HeJ Ovary - Granulosa cell tumor - granulosa cell
  • MMTV - mouse mammary tumor virus
  • corn oil
Ovary - Granulosa cell

observed

C3H/HeJ Ovary - Luteal cell tumor
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Ovary - Luteal cell

observed

C3H/HeJ Ovary - Luteal cell tumor
  • MMTV - mouse mammary tumor virus
  • corn oil
Ovary - Luteal cell

observed

C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Ovary

observed

C3H/HeJ Ovary adenoma - tubular
  • MMTV - mouse mammary tumor virus
  • corn oil
Ovary

observed

C3H/HeJ Ovary cyst
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Ovary

observed

C3H/HeJ Ovary cyst
  • MMTV - mouse mammary tumor virus
  • corn oil
Ovary

observed

C3H/HeJ Peritoneal cavity lesion - nodular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Peritoneal cavity

observed

C3H/HeJ Urinary bladder cyst - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Urinary bladder

observed

C3H/HeJ Urinary bladder neoplasm - cystic
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Urinary bladder

observed

C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

5.26

C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

10.42

C3H/HeJ Uterus - Cervix adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Cervix

2.86

C3H/HeJ Uterus - Cervix adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

6.25

C3HeB/FeJ Uterus - Cervix adenocarcinoma
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

5.41 - 5.56

C3H/HeJ Uterus - Cervix atypia - glandular
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix cyst - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix cyst - papillary
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

observed

C3HeB/FeJ Uterus - Cervix hyperplasia
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

0 - 10.64

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

0 - 36

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

9 - 14

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

0

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

33

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

6 - 89

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Cervix

17.14

C3H/HeJ Uterus - Cervix lesion
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

15

C3H/HeJ Uterus - Cervix lesion
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

29.17

C3HeB/FeJ Uterus - Cervix lesion
  • corn oil
Uterus - Cervix

0 - 11.11

C3HeB/FeJ Uterus - Cervix lesion
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

0 - 61.11

C3HeB/FeJ Uterus - Cervix lesion
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

0 - 45.95

C3HeB/FeJ Uterus - Cervix lesion
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix myoblastoma - granular cell
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix neoplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix neoplasia - glandular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix neoplasia - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix neoplasm - cystic
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix tumor
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Cervix

observed

C3H/HeJ Uterus - Cervix tumor
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Muscle - Striated - Skeletal

observed

C3H/HeJ Uterus - Endometrium hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Endometrium

observed

C3HeB/FeJ Uterus - Endometrium hyperplasia
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Endometrium

observed

C3H/HeJ Uterus - Uterine gland cyst - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine gland

observed

C3H/HeJ Uterus - Uterine gland hyperplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine gland

observed

C3H/HeJ Uterus - Uterine gland neoplasia
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine gland

observed

C3H/HeJ Uterus - Uterine gland neoplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine gland

observed

C3H/HeJ Uterus - Uterine gland neoplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine gland

observed

C3H/HeJ Uterus - Uterine gland neoplasm - cystic
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine gland

observed

C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn adenoacanthoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Uterine horn

2.08

C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

observed - 4.17

C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

3.12

C3H/HeJ Uterus - Uterine horn adenocarcinoma
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

2.63

C3H/HeJ Uterus - Uterine horn atypia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn hyperplasia - glandular
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Uterine horn

25.53

C3H/HeJ Uterus - Uterine horn hyperplasia - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

15.62

C3H/HeJ Uterus - Uterine horn hyperplasia - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

78.95

C3H/HeJ Uterus - Uterine horn hyperplasia - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

100

C3H/HeJ Uterus - Uterine horn hyperplasia - glandular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

24 - 62

C3H/HeJ Uterus - Uterine horn hyperplasia - glandular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

95.83

C3HeB/FeJ Uterus - Uterine horn hyperplasia - glandular
  • corn oil
Uterus - Uterine horn

11.11

C3HeB/FeJ Uterus - Uterine horn hyperplasia - glandular
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

5.13 - 94.59

C3HeB/FeJ Uterus - Uterine horn hyperplasia - glandular
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

88.89

C3H/HeJ Uterus - Uterine horn lesion
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus - Uterine horn

2.13

C3H/HeJ Uterus - Uterine horn lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

3.12

C3H/HeJ Uterus - Uterine horn lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

46

C3H/HeJ Uterus - Uterine horn lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

93

C3H/HeJ Uterus - Uterine horn lesion
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

5.56 - 5.71

C3H/HeJ Uterus - Uterine horn lesion
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

81.25

C3HeB/FeJ Uterus - Uterine horn lesion
  • corn oil
Uterus - Uterine horn

16.67

C3HeB/FeJ Uterus - Uterine horn lesion
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

5.13 - 86.49

C3HeB/FeJ Uterus - Uterine horn lesion
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

33.33

C3H/HeJ Uterus - Uterine horn neoplasia
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn neoplasia
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn neoplasia - glandular
  • MMTV - mouse mammary tumor virus
  • 17beta-estradiol (E2)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn neoplasia - glandular
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn tumor
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus - Uterine horn tumor
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Uterus - Uterine horn

observed

C3H/HeJ Uterus lesion - nodular
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
Uterus

observed

C3H/HeJ Vagina lesion
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
Vagina

observed

C3HeB/FeJ Vagina squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
Vagina

observed

C3HeB/FeJ Vagina squamous cell carcinoma
  • diethylstilbestrol (DES)
  • corn oil
Vagina

2.7

C3H/HeJ (Unspecified organ) tumor - malignant
  • MMTV - mouse mammary tumor virus
  • corn oil
(Unspecified organ)

0

C3H/HeJ (Unspecified organ) tumor - malignant
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
(Unspecified organ)

6.25

C3H/HeJ (Unspecified organ) tumor - malignant
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
(Unspecified organ)

7.89

C3H/HeJ (Unspecified organ) tumor - malignant
  • MMTV - mouse mammary tumor virus
  • diethylstilbestrol (DES)
  • corn oil
(Unspecified organ)

12.5

C3H/HeJ (Unspecified organ) tumor - malignant
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
(Unspecified organ)

5.71

C3H/HeJ (Unspecified organ) tumor - malignant
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
(Unspecified organ)

0

C3H/HeJ (Unspecified organ) tumor - malignant
  • 17beta-estradiol (E2)
  • MMTV - mouse mammary tumor virus
  • corn oil
(Unspecified organ)

10.42

C3HeB/FeJ (Unspecified organ) tumor - malignant
  • corn oil
(Unspecified organ)

0

C3H/HeJ (Unspecified organ) tumor - malignant
  • diethylstilbestrol (DES)
  • corn oil
(Unspecified organ)

0

C3H/HeJ (Unspecified organ) tumor - malignant
  • diethylstilbestrol (DES)
  • corn oil
(Unspecified organ)

5.56 - 10.81