Reference SummaryLuongo C, Cancer Res 1994 Nov 15;54(22):5947-52

Title

Loss of Apc+ in intestinal adenomas from Min mice.

Authors

Luongo C; Moser AR; Gledhill S; Dove WF

Journal

Cancer Res

Volume

54

Issue

22

Year

1994

Pages

5947-52

Abstract

Allelic loss at the Apc locus in spontaneously occurring intestinal adenomas from mice heterozygous for the ApcMin nonsense mutation was analyzed using a site-specific quantitative polymerase chain reaction assay. All 97 of the intestinal adenomas analyzed showed extensive loss of the wild-type Apc (Apc+) allele. Quantitative polymerase chain reaction analysis of loci linked to Apc indicated loss of the chromosome carrying Apc+. Only one copy of the homologue carrying ApcMin remained in the intestinal adenomas. Possible reasons for the difference in the mechanism of Apc+ loss between human and Min mouse intestinal adenomas are discussed.

Links

J:21369 – Mouse Genome Informatics
7954427 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
C57BL/6J-ApcMin/+ Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

observed

AKB6F1-ApcMin/+ Intestine - Large Intestine - Colon adenoma Intestine - Large Intestine - Colon

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

observed

AKB6F1-ApcMin/+ Intestine - Small Intestine - Duodenum adenoma Intestine - Small Intestine - Duodenum

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum

observed

AKB6F1-ApcMin/+ Intestine - Small Intestine - Ileum adenoma Intestine - Small Intestine - Ileum

observed

C57BL/6J-ApcMin/+ Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

observed

AKB6F1-ApcMin/+ Intestine - Small Intestine - Jejunum adenoma Intestine - Small Intestine - Jejunum

observed

C57BL/6J-ApcMin/+ Intestine adenoma Intestine

100

AKB6F1-ApcMin/+ Intestine adenoma Intestine

100