Reference SummarySzabova L, Cancer Res 2012 Aug 15;72(16):4141-53

Title

Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Authors

Szabova L; Yin C; Bupp S; Guerin TM; Schlomer JJ; Householder DB; Baran ML; Yi M; Song Y; Sun W; McDunn JE; Martin PL; Van Dyke T; Difilippantonio S

Journal

Cancer Res

Volume

72

Issue

16

Year

2012

Pages

4141-53

Abstract

The majority of human high-grade serous epithelial ovarian cancer (SEOC) is characterized by frequent mutations in p53 and alterations in the RB and FOXM1 pathways. A subset of human SEOC harbors a combination of germline and somatic mutations as well as epigenetic dysfunction for BRCA1/2. Using Cre-conditional alleles and intrabursal induction by Cre-expressing adenovirus in genetically engineered mice, we analyzed the roles of pathway perturbations in epithelial ovarian cancer initiation and progression. Inactivation of RB-mediated tumor suppression induced surface epithelial proliferation with progression to stage I carcinoma. Additional biallelic inactivation and/or missense p53 mutation in the presence or absence of Brca1/2 caused progression to stage IV disease. As in human SEOC, mice developed peritoneal carcinomatosis, ascites, and distant metastases. Unbiased gene expression and metabolomic profiling confirmed that Rb, p53, and Brca1/2-triple mutant tumors aligned with human SEOC, and not with other intraperitoneal cancers. Together, our findings provide a novel resource for evaluating disease etiology and biomarkers, therapeutic evaluation, and improved imaging strategies in epithelial ovarian cancer.

Links

J:189304 – Mouse Genome Informatics
22617326 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
[not specified] Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

6.9

[not specified]-Brca1tm1Brn Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

0

[not specified]-Brca2tm1Brn Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

15

[not specified]-Trp53tm2Tyj/+ Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

15

[not specified]-Trp53tm1Brn Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

7.1

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

3.7

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

10

[not specified]-Brca1tm1Brn Trp53tm1Brn Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

4.8

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

10

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

3.1

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

9.1

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

27

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

36

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

50

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

16

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

32

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

24

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

37

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

15

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

18

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Leukocyte lymphoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Leukocyte

16

[not specified] Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

14

[not specified]-Brca1tm1Brn Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

11

[not specified]-Brca2tm1Brn Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

10

[not specified]-Trp53tm2Tyj/+ Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

19

[not specified]-Trp53tm1Brn Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

37.5

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

50

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

26

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

62

[not specified]-Brca1tm1Brn Trp53tm1Brn Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

71

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

25

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

66

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

4.5

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

9.1

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

8.3

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

5.3

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

21

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

6.9

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

20

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

20

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Mesodermal cell/mesoblast sarcoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Mesodermal cell/mesoblast

14

[not specified] Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca1tm1Brn Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca2tm1Brn Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Trp53tm2Tyj/+ Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

3.8

[not specified]-Trp53tm1Brn Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

4.5

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

5.3

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

3.4

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

3.3

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary - Germ cell teratoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary - Germ cell

0

[not specified] Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

18

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

20

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

18

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

25

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

42

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

21

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

72

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

70

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

67.5

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

88

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

78

[not specified] Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

18

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

20

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

18

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

17

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

16

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

11

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

24

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

17

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

24

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

14

[not specified] Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

11

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

14

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

2.5

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.9 - 12

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

8.0

[not specified] Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.3

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

15

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.9

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified] Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.3

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0 - 18

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

4.0 - 6.0

[not specified] Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

8.3

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

11

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

3.4

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

6.7 - 10

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0 - 18

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIIA
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

16

[not specified] Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

3.4

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0 - 3.3

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IIIB
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

4.0

[not specified] Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.3

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

17

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

23

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

25

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

29

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma - stage IV
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

20

[not specified] Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0 - 12.5

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

27

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

6.7

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

9.1

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

25

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

26

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

21

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

14

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

13

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.9

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary carcinoma in situ
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

6.0 - 8.0

[not specified] Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm2Tyj/+ Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

4.8

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

27

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

13

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

27

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

25

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

21

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

5.3

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

6.7

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

2.5

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary hyperplasia
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified] Ovary normal tissue (control) Ovary

not applicable

[not specified] Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Brca1tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

0

[not specified]-Brca2tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Trp53tm2Tyj/+ Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

12

[not specified]-Trp53tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

12.5

[not specified]-Trp53tm1Brn/Trp53tm2Tyj Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

14

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

7.4

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

45

[not specified]-Brca1tm1Brn Trp53tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

62

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

10

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

47

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

23

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

20

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

55

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

25

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

42

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

37

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

79

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

77

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

80

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

88

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

84

[not specified]-Brca1tm1Brn/+ Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn Ovary tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
Ovary

observed

[not specified] (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

21

[not specified]-Brca1tm1Brn (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

26

[not specified]-Brca2tm1Brn (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

25

[not specified]-Trp53tm2Tyj/+ (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

62

[not specified]-Trp53tm1Brn (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

37.5

[not specified]-Trp53tm1Brn/Trp53tm2Tyj (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

60

[not specified]-Brca1tm1Brn Trp53tm2Tyj/+ (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

56

[not specified]-Brca1tm1Brn Trp53tm1Brn/Trp53tm2Tyj (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

79

[not specified]-Brca1tm1Brn Trp53tm1Brn (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

76

[not specified]-Brca2tm1Brn Trp53tm2Tyj/+ (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

50

[not specified]-Brca2tm1Brn Trp53tm1Brn/Trp53tm2Tyj (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

72

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

36

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

47

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

64

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

83

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

63

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm2Tyj/+ (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

68

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

93

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

97

[not specified]-Brca2tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn/Trp53tm2Tyj (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

85

[not specified]-Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

88

[not specified]-Brca1tm1Brn Tg(Krt18-EGFP,-TAg121)36Ysng Trp53tm1Brn (Unspecified organ) tumor
  • Ad5-CMV-Cre (AdCre) (AdCMVCre)
(Unspecified organ)

94