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2019-12-01
MTB 3.0
 
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Reference
Title: Combined loss of p21(waf1/cip1) and p27(kip1) enhances tumorigenesis in mice.
Authors: Garcia-Fernandez RA; Garcia-Palencia P; Sanchez MA; Gil-Gomez G; Sanchez B; Rollan E; Martin-Caballero J; Flores JM
Journal: Lab Invest
Volume: 91
Issue: 11
Year: 2011
Pages: 1634-42
Abstract: The cell cycle inhibitors p21(Waf1/Cip1) and p27(Kip1) are frequently downregulated in many human cancers, and correlate with a worse prognosis. We show here that combined deficiency in p21 and p27 proteins in mice is linked to more aggressive spontaneous tumorigenesis, resulting in a decreased lifespan. The most common tumors developed in p21p27 double-null mice were endocrine, with a higher incidence of pituitary adenomas, pheochromocytomas and thyroid adenomas. The combined absence of p21 and p27 proteins delays the incidence of radiation-induced thymic lymphomas with a higher apoptotic rate, measured by active caspase-3 and cleaved PARP-1 immunoexpresion. These results provide experimental evidence for a cooperation of both cyclin-dependent kinase inhibitors in tumorigenesis in mice.
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J:177185  Mouse Genome Informatics
21876534  National Library of Medicine/PubMed