Reference SummaryMattison J, Cancer Res 2010 Feb 1;70(3):883-95

Title

Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach.

Authors

Mattison J; Kool J; Uren AG; de Ridder J; Wessels L; Jonkers J; Bignell GR; Butler A; Rust AG; Brosch M; Wilson CH; van der Weyden L; Largaespada DA; Stratton MR; Futreal PA; van Lohuizen M; Berns A; Collier LS; Hubbard T; Adams DJ

Journal

Cancer Res

Volume

70

Issue

3

Year

2010

Pages

883-95

Abstract

Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites isolated from 1,005 mouse tumors induced with the murine leukemia virus (MuLV). This cross-species oncogenomic analysis revealed candidate tumor suppressor genes and oncogenes mutated in both human and mouse tumors, making them strong candidates for novel cancer genes. A significant number of these genes contained binding sites for the stem cell transcription factors Oct4 and Nanog. Notably, mice carrying tumors with insertions in or near stem cell module genes, which are thought to participate in cell self-renewal, died significantly faster than mice without these insertions. A comparison of the profile we identified to that induced with the Sleeping Beauty (SB) transposon system revealed significant differences in the profile of recurrently mutated genes. Collectively, this work provides a rich catalogue of new candidate cancer genes for functional analysis.

Links

J:156861 – Mouse Genome Informatics
20103622 – National Library of Medicine/PubMed

Models

Strain Model Name Treatment Agent(s) Organ Affected Frequency Model Details
B6FVBF1-Gt(ROSA)26Sortm1(sb11)Njen TgTn(sb-T2/Onc)#Dla CNS - Brain glioma CNS - Brain

observed

FVB.129X1-Cdkn2atm1Cjs Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S7-Trp53tm1Brd Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.Cg-Cdkn2atm1Cjs Cdkn2atm1Rdp Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129P2-Cdkn2btm1Brn Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S-Cdkn1atm1Led Cdkn1btm1Mlf/+ Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S6-Cdkn1atm1Led Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S4-Cdkn1btm1Mlf/+ Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S4-Cdkn1btm1Mlf Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S-Cdkn1atm1Led Cdkn1btm1Mlf Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.Cg-Cdkn2atm1Cjs/+ Cdkn2atm1Rdp/+ Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S-Cdkn1atm1Led/+ Cdkn1btm1Mlf/+ Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129-Cdkn1atm1Led Cdkn2btm1Brn Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S-Cdkn1atm1Led/+ Cdkn1btm1Mlf Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S6-Cdkn1atm1Led/+ Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB.129S7-Trp53tm1Brd/+ Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

FVB Leukocyte - Lymphocyte lymphoma
  • MuLV - murine leukemia virus (MLV)
Leukocyte - Lymphocyte

observed

B6FVBF1-Gt(ROSA)26Sortm1(sb11)Njen TgTn(sb-T2/Onc)#Dla Leukocyte - Lymphocyte lymphoma Leukocyte - Lymphocyte

observed

B6FVBF1-Gt(ROSA)26Sortm1(sb11)Njen TgTn(sb-T2/Onc)#Dla Skin tumor Skin

observed